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Gene Review

Klra16  -  killer cell lectin-like receptor,...

Mus musculus

Synonyms: Klra24, Ly-49P, Ly49P, Ly49x
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High impact information on Klra16

  • These results are suggestive of a new natural killer cell mechanism implicated in MCMV resistance, which depends on the functional interaction of the Ly49P receptor and the major histocompatibility complex class I molecule H-2D(k) on MCMV-infected cells [1].
  • We found that natural killer cell-activating receptor Ly49P specifically recognized MCMV-infected cells, dependent on the presence of the H2 (k) haplotype [1].
  • Experimental infection in mice has revealed that the genetically determined natural resistance to murine CMV (MCMV) may be mediated either by direct recognition between the NK receptor Ly49H and the pathogen-encoded glycoprotein m157 or by epistatic interaction between Ly49P and the host MHC H-2D(k) [2].
  • In addition to the previously characterized Ly49P, two new activating Ly49 proteins were discovered, Ly49R and U [3].
  • Recently, the NK activation receptor Ly49P and MHC class I Dk proteins were genetically implicated in MCMV resistance, in part because Ly49P-expressing reporter T cells could specifically bind Dk molecules on MCMV-infected mouse embryonic fibroblasts (MEFs) [4].

Associations of Klra16 with chemical compounds

  • An immunoreceptor tyrosine-based inhibitory motif-containing, Ly49D-related clone was discovered that we have named Ly49O, and one immunoreceptor tyrosine-based inhibitory motif-lacking, Ly49A-related clone was discovered that we have named Ly49P [5].


  1. Epistasis between mouse Klra and major histocompatibility complex class I loci is associated with a new mechanism of natural killer cell-mediated innate resistance to cytomegalovirus infection. Desrosiers, M.P., Kielczewska, A., Loredo-Osti, J.C., Adam, S.G., Makrigiannis, A.P., Lemieux, S., Pham, T., Lodoen, M.B., Morgan, K., Lanier, L.L., Vidal, S.M. Nat. Genet. (2005) [Pubmed]
  2. Cmv4, a new locus linked to the NK cell gene complex, controls innate resistance to cytomegalovirus in wild-derived mice. Adam, S.G., Caraux, A., Fodil-Cornu, N., Loredo-Osti, J.C., Lesjean-Pottier, S., Jaubert, J., Bubic, I., Jonjic, S., Guénet, J.L., Vidal, S.M., Colucci, F. J. Immunol. (2006) [Pubmed]
  3. Class I MHC-binding characteristics of the 129/J Ly49 repertoire. Makrigiannis, A.P., Pau, A.T., Saleh, A., Winkler-Pickett, R., Ortaldo, J.R., Anderson, S.K. J. Immunol. (2001) [Pubmed]
  4. Deficient major histocompatibility complex-linked innate murine cytomegalovirus immunity in MA/My.L-H2b mice and viral downregulation of H-2k class I proteins. Xie, X., Dighe, A., Clark, P., Sabastian, P., Buss, S., Brown, M.G. J. Virol. (2007) [Pubmed]
  5. Cloning and characterization of a novel activating Ly49 closely related to Ly49A. Makrigiannis, A.P., Gosselin, P., Mason, L.H., Taylor, L.S., McVicar, D.W., Ortaldo, J.R., Anderson, S.K. J. Immunol. (1999) [Pubmed]
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