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Gene Review:

Ubl4 - ubiquitin-like 4

Mus musculus

Synonyms: DXHXS254E, DXS254E, DXS254Eh, Gdx, Ubiquitin-like protein 4A, ...

Filippi, M. et al., Yang, F. et al., Herman, G.E. et al.

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High impact information on Ubl4

Amplification was subsequently performed with clone 8.0 and a subclone, 8.1/1, which retains a small murine X-chromosomal fragment including Hprt and the Gdx locus [1].
The two genes, P3 and GdX (DXS253E and DXS254E), physically linked on the human X chromosome, lie within a similar physical distance on the mouse X chromosome [2].
While Ubl4a is expressed throughout spermatogenesis, Ubl4b is restricted to post-meiotic germ cells [3].

Biological context of Ubl4

Linkage and sequence conservation of the X-linked genes DXS253E (P3) and DXS254E (GdX) in mouse and man [2].
Ubl4b lacks introns and evidently arose from an X-linked intron-bearing housekeeping gene, Ubl4a, by retroposition during mammalian evolution [3].

References

The construction of human somatic cell hybrids containing portions of the mouse X chromosome and their use to generate DNA probes via interspersed repetitive sequence polymerase chain reaction. Herman, G.E., Berry, M., Munro, E., Craig, I.W., Levy, E.R. Genomics (1991) [Pubmed]
Linkage and sequence conservation of the X-linked genes DXS253E (P3) and DXS254E (GdX) in mouse and man. Filippi, M., Tribioli, C., Toniolo, D. Genomics (1990) [Pubmed]
Ubl4b, an X-derived retrogene, is specifically expressed in post-meiotic germ cells in mammals. Yang, F., Skaletsky, H., Wang, P.J. Gene Expr. Patterns (2007) [Pubmed]

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UBL4A	Bos taurus
UBL4A	Canis lupus familiaris
zgc:56596	Danio rerio
UBL4A	Homo sapiens
UBL4A	Macaca mulatta
Slc10a3-ubl4	Mus musculus
UBL4A	Pan troglodytes
Ubl4a	Rattus norvegicus
ubl4a	Xenopus (Silurana) tropicalis

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