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Gene Review:

fyuA - pesticin/yersiniabactin receptor protein

Yersinia pestis biovar Microtus str. 91001

Brem, D. et al., Anisimov, R. et al., Rakin, A. et al., Rakin, A. et al.

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Disease relevance of fyuA

On the basis of the fyuA and irp2 sequence homologies, two evolutionary groups of highly pathogenic Yersinia species can be established [1].
To determine whether irp6, irp7 and fyuA (encoding the outer-membrane Fe-Ybt/pesticin receptor FyuA) are sufficient to mediate Fe-Ybt transport/utilization, these genes were transferred into Escherichia coli entD,F and into non-pathogenic Y. enterocolitica, BG IA, strain NF-O [2].

High impact information on fyuA

Yersinia enterocolitica O:8, biogroup (BG) IB, strain WA-C carries a high-pathogenicity island (HPI) including iron-repressible genes (irp1-9, fyuA) for biosynthesis and uptake of the siderophore yersiniabactin (Ybt) [2].
In this work, we identified the transcriptional start points of YbtA-regulated promoters of the HPI by primer extension, purified homogeneous YbtA and defined the YbtA-binding sites by DNaseI footprint analysis in ybtA, fyuA, irp6, and irp2 promoters [3].
The IS1328 insertion sequence could be responsible for the deletions of the fyuA/irp2 gene cluster observed in Y. enterocolitica O8 and could represent a member of a new group of widely distributed repetitive elements [4].

References

Evidence for two evolutionary lineages of highly pathogenic Yersinia species. Rakin, A., Urbitsch, P., Heesemann, J. J. Bacteriol. (1995) [Pubmed]
Functional analysis of yersiniabactin transport genes of Yersinia enterocolitica. Brem, D., Pelludat, C., Rakin, A., Jacobi, C.A., Heesemann, J. Microbiology (Reading, Engl.) (2001) [Pubmed]
Transcriptional regulation of high pathogenicity island iron uptake genes by YbtA. Anisimov, R., Brem, D., Heesemann, J., Rakin, A. Int. J. Med. Microbiol. (2005) [Pubmed]
Virulence-associated fyuA/irp2 gene cluster of Yersinia enterocolitica biotype 1B carries a novel insertion sequence IS1328. Rakin, A., Heesemann, J. FEMS Microbiol. Lett. (1995) [Pubmed]

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