Gene Review:
phd - prevention of host death by Doc toxicity
Enterobacteria phage P1
- Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained. Lehnherr, H., Maguin, E., Jafri, S., Yarmolinsky, M.B. J. Mol. Biol. (1993)
- Postsegregational killing mediated by the P1 phage "addiction module" phd-doc requires the Escherichia coli programmed cell death system mazEF. Hazan, R., Sat, B., Reches, M., Engelberg-Kulka, H. J. Bacteriol. (2001)
- Stability and DNA binding of the phd protein of the phage P1 plasmid addiction system. Gazit, E., Sauer, R.T. J. Biol. Chem. (1999)
- Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli. Lehnherr, H., Yarmolinsky, M.B. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Autoregulation of the plasmid addiction operon of bacteriophage P1. Magnuson, R., Lehnherr, H., Mukhopadhyay, G., Yarmolinsky, M.B. J. Biol. Chem. (1996)
- The type IC hsd loci of the enterobacteria are flanked by DNA with high homology to the phage P1 genome: implications for the evolution and spread of DNA restriction systems. Tyndall, C., Lehnherr, H., Sandmeier, U., Kulik, E., Bickle, T.A. Mol. Microbiol. (1997)