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Gene Review

phd  -  prevention of host death by Doc toxicity

Enterobacteria phage P1

 
 
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Disease relevance of phd

 

High impact information on phd

 

Biological context of phd

  • Homologs of the P1 addiction genes are found elsewhere, but phd and doc are unrelated to previously described genes of other plasmids that also cause an apparent increase in plasmid stability by post-segregational killing [1].
  • The operon consists of a gene encoding an endotoxin responsible for death on curing (doc), preceded by a gene encoding a relatively unstable antidote that can prevent host death (phd) [5].
 

Other interactions of phd

  • The upstream sequences include functional phd and doc genes, which encode an addiction system that stabilizes the P1 prophage state, and extend to and beyond pac, the site at which phage DNA packaging begins [6].

References

 
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