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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Adamts13  -  a disintegrin-like and metallopeptidase...

Mus musculus

Synonyms: A disintegrin and metalloproteinase with thrombospondin motifs 13, ADAM-TS 13, ADAM-TS13, ADAMTS-13, Gm710, ...
 
 
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Disease relevance of Adamts13

  • Here, we show spontaneous thrombus formation in activated microvenules of Adamts13-/- mice by intravital microscopy [1].
  • Together, these findings shed new light on the potential roles played by ADAMTS13 and VWF in TTP, endotoxemia, and normal hemostasis [2].
 

High impact information on Adamts13

  • Transient expression of the murine Adamts13 cDNA in HEK 293 cells yielded a protein with a molecular weight of approximately 180 kDa which degraded recombinant murine VWF (rVWF) in a dose-dependent manner [3].
 

Analytical, diagnostic and therapeutic context of Adamts13

References

  1. Systemic antithrombotic effects of ADAMTS13. Chauhan, A.K., Motto, D.G., Lamb, C.B., Bergmeier, W., Dockal, M., Plaimauer, B., Scheiflinger, F., Ginsburg, D., Wagner, D.D. J. Exp. Med. (2006) [Pubmed]
  2. The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis. Chauhan, A.K., Walsh, M.T., Zhu, G., Ginsburg, D., Wagner, D.D., Motto, D.G. Blood (2008) [Pubmed]
  3. Cloning, expression and functional characterization of the full-length murine ADAMTS13. Bruno, K., Völkel, D., Plaimauer, B., Antoine, G., Pable, S., Motto, D.G., Lemmerhirt, H.L., Dorner, F., Zimmermann, K., Scheiflinger, F. J. Thromb. Haemost. (2005) [Pubmed]
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