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Gene Review: 

LMOf2365_2473  -  histidine kinase

Listeria monocytogenes serotype 4b str. F2365

 
 
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High impact information on LMOf2365_2473

  • Surprisingly, although controlling the same set of genes as VirR, the putative cognate histidine kinase of VirR, VirS, encoded by a gene located three genes downstream of virR, was shown not to be essential for virulence [1].
  • Following identification of the operon in an acid-tolerant Tn917 mutant, a deletion in the histidine kinase component was shown to result in a growth phase variation in acid tolerance, an ability to grow in high ethanol concentrations, and a significant reduction in virulence [2].

References

  1. VirR, a response regulator critical for Listeria monocytogenes virulence. Mandin, P., Fsihi, H., Dussurget, O., Vergassola, M., Milohanic, E., Toledo-Arana, A., Lasa, I., Johansson, J., Cossart, P. Mol. Microbiol. (2005) [Pubmed]
  2. Identification and disruption of lisRK, a genetic locus encoding a two-component signal transduction system involved in stress tolerance and virulence in Listeria monocytogenes. Cotter, P.D., Emerson, N., Gahan, C.G., Hill, C. J. Bacteriol. (1999) [Pubmed]
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