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Gene Review:

LMOf2365_0866 - amidase

Listeria monocytogenes serotype 4b str. F2365

Turner, M.S. et al., Barclay, R. et al., McLaughlan, A.M. et al., Milohanic, E. et al., Kashige, N. et al.

Turner, Waldherr, Loessner, Giffard,

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Disease relevance of LMOf2365_0866

Ami is an autolytic amidase from Listeria monocytogenes that is targeted to the bacterial surface via its C-terminal cell wall anchoring (CWA) domain [1].
Characterization of the recombinant enzyme expressed in Escherichia coli has revealed it to be an amidase and to be able to hydrolyse a range of peptidoglycan substrates [2].
The amino acid sequence of PL-1 amidase showed a high homology to those of Lactococcus lactis phage rlt and Listeria monocytogenes phage A511 [3].

High impact information on LMOf2365_0866

The production levels, hydrolytic and bacteriocidal activities of the Listeria monocytogenes bacteriophage N-acetylmuramoyl-l-alanine amidase endolysin Ply511 and the glycylglycine endopeptidase lysostaphin were examined [4].
No evidence was found for the presence of RNAase, DNAase, peptidase/amidase, phosphoamidase, alpha-amylase, glucosidase, galactosidase, pyranosidase or glucose aminidase [5].

References

Sequence and binding activity of the autolysin-adhesin Ami from epidemic Listeria monocytogenes 4b. Milohanic, E., Jonquières, R., Glaser, P., Dehoux, P., Jacquet, C., Berche, P., Cossart, P., Gaillard, J.L. Infect. Immun. (2004) [Pubmed]
Molecular characterization of an autolytic amidase of Listeria monocytogenes EGD. McLaughlan, A.M., Foster, S.J. Microbiology (Reading, Engl.) (1998) [Pubmed]
Cloning, sequence analysis, and expression of Lactobacillus casei phage PL-1 lysis genes. Kashige, N., Nakashima, Y., Miake, F., Watanabe, K. Arch. Virol. (2000) [Pubmed]
Antimicrobial activity of lysostaphin and a Listeria monocytogenes bacteriophage endolysin produced and secreted by lactic acid bacteria. Turner, M.S., Waldherr, F., Loessner, M.J., Giffard, P.M. Syst. Appl. Microbiol. (2007) [Pubmed]
Haemolysins and extracellular enzymes of Listeria monocytogenes and L. ivanovii. Barclay, R., Threlfall, D.R., Leighton, I. J. Med. Microbiol. (1989) [Pubmed]

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