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Gene Review

ESR2  -  estrogen receptor 2 (ER beta)

Bos taurus

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Disease relevance of ESR2


High impact information on ESR2


Biological context of ESR2

  • Both ERbeta mRNA and protein expression were highest during the luteal phase in vivo and elevated ERbeta expression levels were observed in vitro after P4 treatment [5].
  • Human and bovine ERbeta amino acid sequences are similar in that their coding region extended farther 5' than initially reported for the published rat ERbeta sequence [1].
  • The cloned full-length receptor contains an open reading frame of 474 amino acids encoding a protein with high homology to the ERbeta sequences from other species [6].
  • Transient transfection studies expressing the two major bovine ERbeta isoforms together with an ERE reporter construct show estrogen-dependent transactivation by the full-length isoform, whereas the isoform lacking the ligand binding domain did not show any transactivation [6].
  • With increasing Zeranol concentrations a significant down-regulation for ERalpha and ERbeta was observed in jejunum (P<0.001 and <0.05, respectively) [7].

Anatomical context of ESR2


Associations of ESR2 with chemical compounds


Other interactions of ESR2


Analytical, diagnostic and therapeutic context of ESR2


  1. Cloning, sequencing, and localization of bovine estrogen receptor-beta within the ovarian follicle. Rosenfeld, C.S., Yuan, X., Manikkam, M., Calder, M.D., Garverick, H.A., Lubahn, D.B. Biol. Reprod. (1999) [Pubmed]
  2. Estradiol and its membrane-impermeable conjugate (estradiol-bovine serum albumin) during in vitro maturation of bovine oocytes: effects on nuclear and cytoplasmic maturation, cytoskeleton, and embryo quality. Beker-van Woudenberg, A.R., van Tol, H.T., Roelen, B.A., Colenbrander, B., Bevers, M.M. Biol. Reprod. (2004) [Pubmed]
  3. Toxic effects of in vitro exposure to p-tert-octylphenol on bovine oocyte maturation and developmental competence. Pocar, P., Augustin, R., Gandolfi, F., Fischer, B. Biol. Reprod. (2003) [Pubmed]
  4. Dominant bovine ovarian follicular cysts express increased levels of messenger RNAs for luteinizing hormone receptor and 3 beta-hydroxysteroid dehydrogenase delta(4),delta(5) isomerase compared to normal dominant follicles. Calder, M.D., Manikkam, M., Salfen, B.E., Youngquist, R.S., Lubahn, D.B., Lamberson, W.R., Garverick, H.A. Biol. Reprod. (2001) [Pubmed]
  5. Expression and localization of estrogen receptor alpha, estrogen receptor beta and progesterone receptor in the bovine oviduct in vivo and in vitro. Ulbrich, S.E., Kettler, A., Einspanier, R. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
  6. Cloning of bovine estrogen receptor beta (ERbeta): expression of novel deleted isoforms in reproductive tissues. Walther, N., Lioutas, C., Tillmann, G., Ivell, R. Mol. Cell. Endocrinol. (1999) [Pubmed]
  7. The gastrointestinal tract as target of steroid hormone action: quantification of steroid receptor mRNA expression (AR, ERalpha, ERbeta and PR) in 10 bovine gastrointestinal tract compartments by kinetic RT-PCR. Pfaffl, M.W., Lange, I.G., Meyer, H.H. J. Steroid Biochem. Mol. Biol. (2003) [Pubmed]
  8. Expression and localisation of oestrogen and progesterone receptors in the bovine mammary gland during development, function and involution. Schams, D., Kohlenberg, S., Amselgruber, W., Berisha, B., Pfaffl, M.W., Sinowatz, F. J. Endocrinol. (2003) [Pubmed]
  9. Cell-specific localization of oestrogen receptor beta (ESR2) mRNA within various bovine ovarian cell types using in situ hybridization. D'Haeseleer, M., Van Poucke, M., Van den Broeck, W. Anatomia, histologia, embryologia. (2005) [Pubmed]
  10. Estrogen receptor alpha and beta expression in the porcine ovary. Słomczyńska, M., Duda, M., Galas, J. Folia Histochem. Cytobiol. (2001) [Pubmed]
  11. Chromosomal mapping and quantitative analysis of estrogen-related receptor alpha-1, estrogen receptors alpha and beta and progesterone receptor in the bovine mammary gland. Connor, E.E., Wood, D.L., Sonstegard, T.S., da Mota, A.F., Bennett, G.L., Williams, J.L., Capuco, A.V. J. Endocrinol. (2005) [Pubmed]
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