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Gene Review

EXT2  -  exostosin glycosyltransferase 2

Bos taurus

 
 
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High impact information on EXT2

  • The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate [1].
  • We report genetic evidence for the exclusion of two genes previously suggested as candidates (EXT2 and ALX4) and describe the identification of a doublet mutation in complete linkage disequilibrium with syndactyly in one gene of the critical interval: LRP4 [2].

References

  1. The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate. Lind, T., Tufaro, F., McCormick, C., Lindahl, U., Lidholt, K. J. Biol. Chem. (1998) [Pubmed]
  2. Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle. Duchesne, A., Gautier, M., Chadi, S., Grohs, C., Floriot, S., Gallard, Y., Caste, G., Ducos, A., Eggen, A. Genomics (2006) [Pubmed]
 
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