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Gene Review

HEXA  -  hexosaminidase A (alpha polypeptide)

Bos taurus

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High impact information on HEXA

  • (2) Larger oligosaccharides containing keratanase II susceptible bonds are produced which are resistant to further degradation, e.g., tetrasaccharides from the sulfated poly(N-acetyllactosamine) repeat sequence, fucose-containing penta- and hexasaccharides, and hexa- and heptasaccharides from the linkage region [1].
  • The pattern of accumulation of intermediate (hepta-, hexa-, and pentacarboxylate porphyrinogens) and final (coproporphyrinogen) decarboxylation products is affected by the ratio of substrate (uroporphyrinogen I or III) concentration to enzyme concentration [2].
  • MATERIALS AMD METHODS: delta-aminolevulinic acid dehydratase (ALA-D) and porphobilinogen deaminase (PBG-D) partially purified from bovine liver, were exposed to 10 microM uroporphyrin (Uro), phyriaporphyrin (Phyria), hexaporphyrin (Hexa), pentaporphyrin (Penta), coproporphyrin (Copro) or protoporphyrin (Proto), either in the dark or under UV light [3].
  • Photodegradation products of the major hexa- and heptabromobiphenyl isomers showed more but still minor (approximately 3%) biodegradation in soil [4].
  • 1H-NMR studies at 500 MHz of a neutral disaccharide and sulphated di-, tetra-, hexa- and larger oligosaccharides obtained by endo-beta-galactosidase treatment of keratan sulphate [5].
 

Anatomical context of HEXA

  • Three trisaccharides, tetra-, penta-, hexa- and certain higher oligosaccharides were obtained from ovine colostrum as free forms [6].
  • This frequency and those of other structure-sensitive bands implied that the heme iron of oxidized P-450SCC adopts the hexa-coordinate high-spin structure, in contrast with the high-spin type cytochrome P-450 purified from phenobarbital- or 3-methylcholanthrene-treated rabbit liver microsomes which presumably have a penta-coordinate structure [7].
 

Associations of HEXA with chemical compounds

  • 6. AII was cleared with 41% efficiency, with generation of penta-, hexa-, and heptapeptides [8].
  • The quantity of long pyrimidine clusters (hexa- and others) is 2--4 times lower in mtDNA than in nDNA [9].
 

Analytical, diagnostic and therapeutic context of HEXA

  • In this way sequences of a suitable length (21-52 residues) for epitope mapping by synthesis of overlapping hexa- and octapeptides were identified [10].

References

  1. Oligosaccharides derived from bovine articular cartilage keratan sulfates after keratanase II digestion: implications for keratan sulfate structural fingerprinting. Brown, G.M., Huckerby, T.N., Morris, H.G., Abram, B.L., Nieduszynski, I.A. Biochemistry (1994) [Pubmed]
  2. Purification and characterization of bovine hepatic uroporphyrinogen decarboxylase. Straka, J.G., Kushner, J.P. Biochemistry (1983) [Pubmed]
  3. Photodynamic and light independent action of 8 to 2 carboxylic free porphyrins on some haem-enzymes. Afonso, S.G., Enríquez de Salamanca, R., Batlle, A. Int. J. Biochem. Cell Biol. (2001) [Pubmed]
  4. Field concentrations and persistence of polybrominated biphenyls in soils and solubility of PBB in natural waters. Jacobs, L.W., Chou, S.F., Tiedje, J.M. Environ. Health Perspect. (1978) [Pubmed]
  5. 1H-NMR studies at 500 MHz of a neutral disaccharide and sulphated di-, tetra-, hexa- and larger oligosaccharides obtained by endo-beta-galactosidase treatment of keratan sulphate. Hounsell, E.F., Feeney, J., Scudder, P., Tang, P.W., Feizi, T. Eur. J. Biochem. (1986) [Pubmed]
  6. New galactosyllactose containing alpha-glycosidic linkage isolated from ovine (Booroola dorset) colostrum. Urashima, T., Saito, T., Nishimura, J., Ariga, H. Biochim. Biophys. Acta (1989) [Pubmed]
  7. Resonance Raman spectra of bovine adrenal cytochrome P-450SCC. Shimizu, T., Kitagawa, T., Mitani, F., Iizuka, T., Ishimura, Y. Biochim. Biophys. Acta (1981) [Pubmed]
  8. Metabolism of tetradecapeptide, angiotensinogen and angiotensin I and II by isolated perfused rat hindlimbs. Campbell, D.J., Ziogas, J., Kladis, A. Clin. Exp. Pharmacol. Physiol. (1990) [Pubmed]
  9. Structure of animal mitochondrial DNA (base composition, pyrimidine clusters, character of methylation). Vanyushin, B.F., Kirnos, M.D. Biochim. Biophys. Acta (1977) [Pubmed]
  10. Mapping the locations of the epitopes of five monoclonal antibodies to the core protein of dermatan sulfate proteoglycan II (decorin). Scott, P.G., Dodd, C.M., Pringle, G.A. J. Biol. Chem. (1993) [Pubmed]
 
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