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Gene Review

HRH1  -  histamine receptor H1

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Disease relevance of HRH1


High impact information on HRH1


Biological context of HRH1


Anatomical context of HRH1


Associations of HRH1 with chemical compounds


Other interactions of HRH1

  • Using cloned histamine H1 receptor cDNA, we found that [3H]mepyramine could bind only the H1 receptor and did not bind MBP in the presence of 10(-5) M quinine, an inhibitor of debrisoquine 4-hydroxylase isozymes [12].


  1. Expression and characterization of the bovine histamine H1 receptor in cDNA-transfected C6 astroglioma cells. Mizuguchi, H., Ito, S., Shevchenko, V.I., Nagasawa, Y., Yamashita, M., Imamura, I., Horio, Y., Fujimoto, K., Fukui, H. J. Biochem. (1994) [Pubmed]
  2. Expression cloning of a cDNA encoding the bovine histamine H1 receptor. Yamashita, M., Fukui, H., Sugama, K., Horio, Y., Ito, S., Mizuguchi, H., Wada, H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  3. Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the role of intracellular Ca2+ in the histamine H1 receptor-stimulated phosphorylation of Ser8, Ser19, Ser31, and Ser40. Bunn, S.J., Sim, A.T., Herd, L.M., Austin, L.M., Dunkley, P.R. J. Neurochem. (1995) [Pubmed]
  4. Histamine-evoked chromaffin cell scinderin redistribution, F-actin disassembly, and secretion: in the absence of cortical F-actin disassembly, an increase in intracellular Ca2+ fails to trigger exocytosis. Zhang, L., Rodríguez Del Castillo, A., Trifaró, J.M. J. Neurochem. (1995) [Pubmed]
  5. Histamine H1 receptor-mediated Ca2+ signaling in cultured bovine corneal endothelial cells. Crawford, K.M., MacCallum, D.K., Ernst, S.A. Invest. Ophthalmol. Vis. Sci. (1992) [Pubmed]
  6. Desensitization of the histamine H1-receptor and transcriptional down-regulation of histamine H1-receptor gene expression in bovine tracheal smooth muscle. Pype, J.L., Mak, J.C., Dupont, L.J., Verleden, G.M., Barnes, P.J. Br. J. Pharmacol. (1998) [Pubmed]
  7. Characterization of vascular histamine H1-receptors: multiple affinity states of aortic histamine H1-receptor. Carman-Krzan, M. Agents Actions (1985) [Pubmed]
  8. The effect of group selective reagents N-ethylmaleimide and dithiothreitol on histamine H1-receptor binding sites in the vascular smooth muscle membranes. Carman-Krzan, M. Agents Actions (1984) [Pubmed]
  9. Contractile properties of synthetic cationic polypeptides in guinea-pig isolated trachea. Spina, D., Goldie, R.G. Br. J. Pharmacol. (1994) [Pubmed]
  10. Evidence that histamine is involved as a mediator of endothelium-dependent contraction induced by A23187 in bovine intrapulmonary vein. Gruetter, C.A., Lemke, S.M., Valentovic, M.A., Szarek, J.L. Eur. J. Pharmacol. (1994) [Pubmed]
  11. Mechanism of histamine-induced calcium efflux from cultured bovine adrenal chromaffin cells: possible involvement of an Na+/Ca2+ exchange mechanism. Houchi, H., Kitamura, K., Minakuchi, K., Ishimura, Y., Okuno, M., Ohuchi, T., Oka, M. Neurosci. Lett. (1994) [Pubmed]
  12. Re-examination of [3H]mepyramine binding assay for histamine H1 receptor using quinine. Liu, Y.Q., Horio, Y., Mizuguchi, H., Fujimoto, K., Imamura, I., Abe, Y., Fukui, H. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
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