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Gene Review

ODC1  -  ornithine decarboxylase 1

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Disease relevance of ODC1

  • In intact rat lungs, hypoxia depresses ornithine decarboxylase activity, the initial rate-limiting enzyme in de novo polyamine synthesis, and enhances uptake of PUT from the vascular compartment, thus suggesting that increased polyamine transport is the driving mechanism behind hypoxia-induced increases in lung polyamine contents [1].
  • The native ODC of E. coli is activated by ATP, GTP, CTP and UTP at 10(-3) M concentration to around 170-300% [2].
  • The role of Na+ and Na(+)-H+ exchange in the stimulation of ornithine decarboxylase (ODC) activity has been investigated in a human colon adenocarcinoma cell line, LoVo [3].

High impact information on ODC1


Biological context of ODC1


Anatomical context of ODC1


Associations of ODC1 with chemical compounds


Regulatory relationships of ODC1


Other interactions of ODC1


Analytical, diagnostic and therapeutic context of ODC1


  1. Multiple polyamine transport pathways in cultured pulmonary artery smooth muscle cells: regulation by hypoxia. Aziz, S.M., Olson, J.W., Gillespie, M.N. Am. J. Respir. Cell Mol. Biol. (1994) [Pubmed]
  2. Allosteric activation by nucleotides of the inactive by phosphatase ornithine decarboxylase of Escherichia coli. Anagnostopoulos, C., Choli, T., Kyriakidis, D.A. Biochem. Int. (1992) [Pubmed]
  3. Regulation of ornithine decarboxylase activity in LoVo cells. McCormack, S.A., Tague, L.L., Gragoe, E.J., Johnson, L.R. Am. J. Physiol. (1990) [Pubmed]
  4. Different early-signaling pathways coupled to transcriptional and posttranscriptional regulation of gene expression during mitogenic activation of T lymphocytes. White, M.W., Oberhauser, A.K., Kuepfer, C.A., Morris, D.R. Mol. Cell. Biol. (1987) [Pubmed]
  5. Mutant strain of Chinese hamster ovary cells with no detectable ornithine decarboxylase activity. Pohjanpelto, P., Hölttä, E., Jänne, O.A. Mol. Cell. Biol. (1985) [Pubmed]
  6. Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro. Takigawa, M., Enomoto, M., Nishida, Y., Pan, H.O., Kinoshita, A., Suzuki, F. Cancer Res. (1990) [Pubmed]
  7. Molecular cloning of a bovine ornithine decarboxylase cDNA and its use in the detection of restriction fragment length polymorphisms in Holsteins. Yao, J., Zadworny, D., Kühnlein, U., Hayes, J.F. Genome (1995) [Pubmed]
  8. Role of polyamines in estradiol-induced growth of human breast cancer cells. Lima, G., Shiu, R.P. Cancer Res. (1985) [Pubmed]
  9. Inhibition of the synthesis of polyamines and DNA in activated lymphocytes by a combination of alpha-methylornithine and methylglyoxal bis(guanylhydrazone). Morris, D.R., Jorstad, C.M., Seyfried, C.E. Cancer Res. (1977) [Pubmed]
  10. Effects of synthetic analogs and fragments of bovine parathyroid hormone on adenosine 3',5'-monophosphate level, ornithine decarboxylase activity, and glycosaminoglycan synthesis in rabbit costal chondrocytes in culture: structure-activity relations. Takano, T., Takigawa, M., Shirai, E., Suzuki, F., Rosenblatt, M. Endocrinology (1985) [Pubmed]
  11. Mitogenic signaling pathways regulating expression of c-myc and ornithine decarboxylase genes in bovine T-lymphocytes. Morris, D.R., Allen, M.L., Rabinovitch, P.S., Kuepfer, C.A., White, M.W. Biochemistry (1988) [Pubmed]
  12. Effect of thyrotropin on ornithine decarboxylase and of polyamines on RNA polymerase in the thyroid. Spaulding, S.W. Endocrinology (1977) [Pubmed]
  13. Epidermal growth factor stimulates ornithine decarboxylase activity in cultured mammalian keratinocytes. Fleckman, P., Langdon, R., McGuire, J. J. Invest. Dermatol. (1984) [Pubmed]
  14. Calcium stimulates ornithine decarboxylase activity in cultured mammalian epithelial cells. Langdon, R.C., Fleckman, P., McGuire, J. J. Cell. Physiol. (1984) [Pubmed]
  15. Physiological effects in bovine lymphocytes of inhibiting polyamine synthesis with ethylglyoxal bis(guanylhydrazone). Igarashi, K., Morris, D.R. Cancer Res. (1984) [Pubmed]
  16. Comparison of specificity of inhibition of polyamine synthesis in bovine lymphocytes by ethylglyoxal bis(guanylhydrazone) and methylglyoxal bis(guanylhydrazone). Igarashi, K., Porter, C.W., Morris, D.R. Cancer Res. (1984) [Pubmed]
  17. Polyamine transport and ornithine decarboxylase activity in hypoxic pulmonary artery smooth muscle cells. Haven, C.A., Olson, J.W., Arcot, S.S., Gillespie, M.N. Am. J. Respir. Cell Mol. Biol. (1992) [Pubmed]
  18. Effects of vasoactive intestinal peptide on adenosine 3',5'-monophosphate, ornithine decarboxylase, and cell growth in a human colon cell line. Yu, D., Seitz, P.K., Selvanayagam, P., Rajaraman, S., Townsend, C.M., Cooper, C.W. Endocrinology (1992) [Pubmed]
  19. Androgen induces ornithine decarboxylase gene expression in colonic cell line HT-29. Cintron, J.R., Asadi, F.K., Malakouti, S., Abcarian, H.A. Dis. Colon Rectum (1996) [Pubmed]
  20. Effect of endogenous digitalis-like factor on endothelin secretion from bovine endothelial cells. Yamada, K., Goto, A., Sugimoto, T. J. Cardiovasc. Pharmacol. (1991) [Pubmed]
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