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Gene Review:

PAX8 - paired box gene 8

Bos taurus

This record was replaced with 534661.

Lòpez-Corrales, N.L. et al., Sonstegard, T.S. et al., Opitz, R. et al.

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High impact information on PAX8

1. In this study, we examined the mRNA expression of NIS, Pax8 and Nkx2.1 in the thyroid gland of Xenopus laevis tadpoles by semi-quantitative reverse transcriptase (RT)-PCR [1].
In addition, it could be shown that thyroid glands of X. laevis tadpoles express Pax8 and Nkx2.1 mRNA in a developmentally regulated manner and that ex vivo treatment of thyroid glands with bTSH, forskolin, and cAMP analogs increased the expression of Pax8 and Nkx2.1 mRNA [1].
The cytogenetic position of PAX8 on BTA 11 and on its homologue OAR 3p lies in the region where the interleukin beta (IL1B) gene has been previously located, (BTA 11q22. 1-->q22.3 and OAR 3p25-->q26 respectively; Lòpez-Corrales et al., 1998) [2].
Physical mapping of the bovine, caprine and ovine homologues of the paired box gene PAX8 [2].
In addition, the breakpoint in conserved synteny can now be narrowed to a position between the protein C (PROC) and PAX8 genes, which lie in close proximity on HSA 2 [2].

Biological context of PAX8

The PAX8 gene, a member of the human paired box gene family, was mapped by FISH to chromosome 11 in cattle and goat and to the short arm of chromosome 3 in sheep [2].
In addition, ms markers developed from cosmids containing either IL1B or PAX8, map to positions 56.6 and 56.9 CM in the BTA11 linkage group, respectively [3].

References

Expression of sodium-iodide symporter mRNA in the thyroid gland of Xenopus laevis tadpoles: developmental expression, effects of antithyroidal compounds, and regulation by TSH. Opitz, R., Trubiroha, A., Lorenz, C., Lutz, I., Hartmann, S., Blank, T., Braunbeck, T., Kloas, W. J. Endocrinol. (2006) [Pubmed]
Physical mapping of the bovine, caprine and ovine homologues of the paired box gene PAX8. Lòpez-Corrales, N.L., Sonstegard, T.S., Smith, T.P. Cytogenet. Cell Genet. (1999) [Pubmed]
Refinement of bovine chromosome 2 linkage map near the mh locus reveals rearrangements between the bovine and human genomes. Sonstegard, T.S., Kappes, S.M., Keele, J.W., Smith, T.P. Anim. Genet. (1998) [Pubmed]

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