The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TAC3  -  tachykinin 3

Bos taurus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on TAC3

  • Mammals contain three distinct tachykinin neuropeptides, substance P, substance K and neuromedin K, and it has been suggested that there are multiple tachykinin receptors [1].
  • The deduced amino acid sequence indicates that the bovine neuromedin K precursor (preprotachykinin B) consists of 126 amino acid residues including a putative signal peptide [2].
  • The MIHC mRNA shares its 3' sequence with the 5' sequence of the preprotachykinin B mRNA encoding the precursor for the neuromedin K neuropeptide [3].
  • Culture of bovine articular chondrocytes with SP or with the related mammalian tachykinins neurokinin A or B (NKA or NKB) produced no effect on prostaglandin E2 (PGE2) or collagenase production [4].
  • Although other neurokinins, such as neurokinin A (NKA) and neurokinin B (NKB), were also effective in secreting cortisol, SP was the most potent among the tested neurokinins, the potency order being SP greater than NKA much greater than NKB [5].

Biological context of TAC3


Anatomical context of TAC3

  • The concentration of SP-like immunoreactivity in the adrenal medulla was found to be substantially higher than that of NKA-like and NKB-like immunoreactivity [7].

Associations of TAC3 with chemical compounds

  • Both septide and NKB treatment at 10(-8) and 10(-7) mol/kg enhanced intestinal transit [6].

Analytical, diagnostic and therapeutic context of TAC3


  1. cDNA cloning of bovine substance-K receptor through oocyte expression system. Masu, Y., Nakayama, K., Tamaki, H., Harada, Y., Kuno, M., Nakanishi, S. Nature (1987) [Pubmed]
  2. Structure and gene organization of bovine neuromedin K precursor. Kotani, H., Hoshimaru, M., Nawa, H., Nakanishi, S. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. Identification of a new type of mammalian myosin heavy chain by molecular cloning. Overlap of its mRNA with preprotachykinin B mRNA. Hoshimaru, M., Nakanishi, S. J. Biol. Chem. (1987) [Pubmed]
  4. The substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca2+ and collagenase production in bovine articular chondrocytes. Halliday, D.A., McNeil, J.D., Betts, W.H., Scicchitano, R. Biochem. J. (1993) [Pubmed]
  5. Cortisol secretion induced by substance P from bovine adrenocortical cells and its inhibition by calmodulin inhibitors. Yoshida, T., Mio, M., Tasaka, K. Biochem. Pharmacol. (1992) [Pubmed]
  6. Rat gastrointestinal motor responses mediated via activation of neurokinin receptors. Chang, F.Y., Lee, S.D., Yeh, G.H., Wang, P.S. J. Gastroenterol. Hepatol. (1999) [Pubmed]
  7. Identification of multiple tachykinins in bovine adrenal medulla using an improved chromatographic procedure. Cheung, N.S., Basile, S., Livett, B.G. Neuropeptides (1993) [Pubmed]
WikiGenes - Universities