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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ACTR3  -  ARP3 actin-related protein 3 homolog (yeast)

Bos taurus

 
 
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Disease relevance of ACTR3

 

High impact information on ACTR3

  • Our results revealed that ARF1 activation leads to greatly increased Arp3 levels on the membranes [2].
  • Analysis of actin and actin-related protein 3 (ARP3) gene expression following induction of hyphal tip formation and apolar growth in Neurospora [3].
  • On isolated plasma membrane ghosts derived from tobacco leaf protoplasts, a putative Arp3 was localized along cortical actin filaments [4].
  • In the inner cortex of maize roots, Arp3 was localized to actin-rich plasmodesmata and pit fields and to multivesicular bodies in the cytoplasm [4].
 

Analytical, diagnostic and therapeutic context of ACTR3

  • Using a polymerase chain reaction (PCR)-generated gene fragment as a probe, we isolated and sequenced a gene encoding an actin-related protein belonging to the Arp3 family from the pufferfish, Fugu rubripes [5].

References

  1. Identification of cofilin, coronin, Rac and capZ in actin tails using a Listeria affinity approach. David, V., Gouin, E., Troys, M.V., Grogan, A., Segal, A.W., Ampe, C., Cossart, P. J. Cell. Sci. (1998) [Pubmed]
  2. Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes. Chen, J.L., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Stamnes, M. FEBS Lett. (2004) [Pubmed]
  3. Analysis of actin and actin-related protein 3 (ARP3) gene expression following induction of hyphal tip formation and apolar growth in Neurospora. Tinsley, J.H., Lee, I.H., Minke, P.F., Plamann, M. Mol. Gen. Genet. (1998) [Pubmed]
  4. Immunological evidence for the presence of plant homologues of the actin- related protein Arp3 in tobacco and maize: subcellular localization to actin-enriched pit fields and emerging root hairs. Van Gestel, K., Slegers, H., Von Witsch, M., Samaj, J., Baluska, F., Verbelen, J.P. Protoplasma (2003) [Pubmed]
  5. Genomic structure and sequence of the pufferfish (Fugu rubripes) gene encoding an actin-related protein. Venkatesh, B., Brenner, S. Gene (1998) [Pubmed]
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