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ADRB2  -  adrenoceptor beta 2, surface

Bos taurus

 
 
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Disease relevance of ADRB2

 

High impact information on ADRB2

  • The ability of a system to regulate its responsiveness in the presence of a continuous stimulus, often termed desensitization, has been extensively characterized for the beta2-adrenergic receptor (beta2AR). beta2AR signalling is rapidly attenuated through receptor phosphorylation and subsequent binding of the protein beta-arrestin [4].
  • When this clone was inserted into a mammalian expression vector and transfected into COS-7 cells, a protein that specifically phosphorylated the agonist-occupied form of the beta 2-adrenergic receptor and phosphorylated, much more weakly, the light-bleached form of rhodopsin was expressed [5].
  • Unlike native protein, upon agonist activation, this mutant arrestin3 expressed in COS1 cells neither supported beta2-adrenergic receptor internalization nor did it concentrate in coated pits, although it was recruited to the plasma membrane [6].
  • Increase in angiotensin secretion induced by isoproterenol (10 microM) can be inhibited by beta 2-adrenoceptor antagonist ICI 118,551 (1 microM), but not by beta 1-adrenoceptor antagonist atenolol (1 microM) [7].
  • Competition curves with selective beta 1- and beta 2-adrenergic receptor agonists and antagonists again demonstrated a pattern for coronary artery intermediate to that of heart and lung, further confirming the presence of both beta-adrenergic receptor subtypes in large coronary arteries, with a ratio of beta 1: beta 2 of 1.5-2.0:1 [8].
 

Biological context of ADRB2

 

Anatomical context of ADRB2

 

Associations of ADRB2 with chemical compounds

 

Regulatory relationships of ADRB2

 

Other interactions of ADRB2

 

Analytical, diagnostic and therapeutic context of ADRB2

References

  1. Cardiovascular effects of clenbuterol are beta 2-adrenoceptor-mediated in steers. Hoey, A.J., Matthews, M.L., Badran, T.W., Pegg, G.G., Sillence, M.N. J. Anim. Sci. (1995) [Pubmed]
  2. Therapeutic clenbuterol treatment does not alter Ca2+ sensitivity of permeabilized fast muscle fibres from exercise trained or untrained horses. Plant, D.R., Kearns, C.F., McKeever, K.H., Lynch, G.S. J. Muscle Res. Cell. Motil. (2003) [Pubmed]
  3. Effect of a beta 2-sympathomimetic on gastrin release, acid secretion, and blood glucose during basal conditions and in response to insulin, 2-deoxy-D-glucose, and feeding in the dog. Gottrup, F., Løvgreen, N.A., Andersen, D. Scand. J. Gastroenterol. (1981) [Pubmed]
  4. Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Goodman, O.B., Krupnick, J.G., Santini, F., Gurevich, V.V., Penn, R.B., Gagnon, A.W., Keen, J.H., Benovic, J.L. Nature (1996) [Pubmed]
  5. Beta-adrenergic receptor kinase: primary structure delineates a multigene family. Benovic, J.L., DeBlasi, A., Stone, W.C., Caron, M.G., Lefkowitz, R.J. Science (1989) [Pubmed]
  6. Arrestin function in G protein-coupled receptor endocytosis requires phosphoinositide binding. Gaidarov, I., Krupnick, J.G., Falck, J.R., Benovic, J.L., Keen, J.H. EMBO J. (1999) [Pubmed]
  7. Endothelial renin-angiotensin pathway. Adrenergic regulation of angiotensin secretion. Tang, S.S., Stevenson, L., Dzau, V.J. Circ. Res. (1990) [Pubmed]
  8. Subtypes of beta-adrenergic receptors in bovine coronary arteries. Vatner, D.E., Knight, D.R., Homcy, C.J., Vatner, S.F., Young, M.A. Circ. Res. (1986) [Pubmed]
  9. Characterization and localization of beta2-adrenergic receptors in the bovine oviduct: indication for progesterone-mediated expression. Einspanier, R., Gabler, C., Kettler, A., Kloas, W. Endocrinology (1999) [Pubmed]
  10. Genetic mapping of the ADRB2 gene on cattle chromosome 7. Schimpf, R.J., Schmutz, S.M., Buchanan, F.C. Anim. Genet. (2001) [Pubmed]
  11. The affinity of betaxolol, a beta 1-adrenoceptor-selective blocking agent, for beta-adrenoceptors in the bovine trachea and heart. Satoh, E., Narimatsu, A., Hosohata, Y., Tsuchihashi, H., Nagatomo, T. Br. J. Pharmacol. (1993) [Pubmed]
  12. The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis. Dohlman, H.G., Bouvier, M., Benovic, J.L., Caron, M.G., Lefkowitz, R.J. J. Biol. Chem. (1987) [Pubmed]
  13. Dissociation between beta-adrenoceptor-mediated cyclic AMP accumulation and inhibition of histamine-stimulated phosphoinositide metabolism in airways smooth muscle. Chilvers, E.R., Lynch, B.J., Challiss, R.A. Biochem. Pharmacol. (1997) [Pubmed]
  14. Calcium mobilization and isometric tension in bovine tracheal smooth muscle: effects of salbutamol and histamine. Hirsh, A.J., Benishin, C.G., Jones, R.L., Pang, P.K., Man, S.F. Cell Calcium (1996) [Pubmed]
  15. Characterization of beta-adrenoceptor subtypes and indications for two cell populations in isolated bovine mesenteric lymphatic vessels. Mahe, L., Chapelain, B., Gargouil, Y.M., Neliat, G. Eur. J. Pharmacol. (1991) [Pubmed]
  16. Alpha1c- and beta2-adrenergic receptor mRNA distribution in the bovine mammary gland detected by competitive RT-PCR. Wellnitz, O., Zurbriggen, A., Friis, R.R., Blum, J.W., Bruckmaier, R.M. J. Dairy Res. (2001) [Pubmed]
  17. Beta 2-adrenoceptors mediate a reduction in endothelial permeability in vitro. Allen, M.J., Coleman, R.A. Eur. J. Pharmacol. (1995) [Pubmed]
  18. Quantitative evaluation of the beta 2-adrenoceptor affinity of phenoxypropanolamines and phenylethanolamines. IJzerman, A.P., Aué, G.H., Bultsma, T., Linschoten, M.R., Timmerman, H. J. Med. Chem. (1985) [Pubmed]
  19. Selective inhibition of a high affinity type IV cyclic AMP phosphodiesterase in bovine trachealis by AH 21-132. Relevance to the spasmolytic and anti-spasmogenic actions of AH 21-132 in the intact tissue. Giembycz, M.A., Barnes, P.J. Biochem. Pharmacol. (1991) [Pubmed]
  20. Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system. Kim, C.M., Dion, S.B., Onorato, J.J., Benovic, J.L. Receptor (1993) [Pubmed]
  21. Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases. Premont, R.T., Koch, W.J., Inglese, J., Lefkowitz, R.J. J. Biol. Chem. (1994) [Pubmed]
  22. Quantitative evaluation of the beta 2-adrenoceptor intrinsic activity of N-tert-butylphenylethanolamines. IJzerman, A.P., Bultsma, T., Timmerman, H. J. Med. Chem. (1986) [Pubmed]
 
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