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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CYP21  -  cytochrome P450, subfamily XXI (steroid 21...

Bos taurus

 
 
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High impact information on CYP21

  • Mapping of bovine markers CYP21, PRL, and BOLA DRBP1 by genetic linkage analysis in reference pedigrees [1].
  • Close genetic linkage between DRBP1 and CYP21 in the MHC of cattle [2].
  • Five paternal half sib families of German Angus (GA) (n = 428) and six of German Simmental (GS) (n = 378) including dams were genotyped with 11 microsatellites (INRA132, RM033, BM1815, BM1258, BOLA-DRB1, BM1818, BM1905, BM1443, CYP21, CSSM5 and DYMS1) derived from chromosome 23 [3].
  • HpaII PCR-RFLP within a Bov-A2 element in the promoter of the bovine CYP21 (steroid 21-hydroxylase) gene [4].
 

Biological context of CYP21

  • Marker CYP21 (steroid 21-hydroxylase) on chromosome 23 was associated with an effect of slightly less than half a phenotypic standard deviation and accounted for approximately 4% of phenotypic variation [5].

References

  1. Mapping of bovine markers CYP21, PRL, and BOLA DRBP1 by genetic linkage analysis in reference pedigrees. Creighton, P., Eggen, A., Fries, R., Jordan, S.A., Hetzel, J., Cunningham, E.P., Humphries, P. Genomics (1992) [Pubmed]
  2. Close genetic linkage between DRBP1 and CYP21 in the MHC of cattle. Gwakisa, P., Mikko, S., Andersson, L. Mamm. Genome (1994) [Pubmed]
  3. Differences in recombination rates on chromosome 23 between German Angus and German Simmental and breed specific linkage mapping. Weimann, C., Kraus, M., Gauly, M., Erhardt, G. Anim. Genet. (2003) [Pubmed]
  4. HpaII PCR-RFLP within a Bov-A2 element in the promoter of the bovine CYP21 (steroid 21-hydroxylase) gene. Damiani, G., Florio, S., Budelli, E., Bolla, P., Caroli, A. Anim. Genet. (2000) [Pubmed]
  5. A search for quantitative trait loci for ovulation rate in cattle. Blattman, A.N., Kirkpatrick, B.W., Gregory, K.E. Anim. Genet. (1996) [Pubmed]
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