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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

KCNH1  -  potassium voltage-gated channel, subfamily...

Bos taurus

Synonyms: EAG, bEAG
 
 
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High impact information on KCNH1

  • Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel [1].
  • Low concentrations of dofetilide produced block of bEAG T432S/A443S; unlike HERG, block was almost irreversible [2].
  • Comparison of EAG currents with IKx, a noninactivating K+ current in the inner segment of rod photoreceptors, reveals an intriguing similarity, suggesting that EAG polypeptides are involved in the formation of Kx channels [3].
  • These included 1-octen-3-ol, 6-methyl-5-hepten-2-one, (Z)-3-hexen-1-ol, naphthalene, and all EAG active compounds identified from urine [4].
  • The expression of surface receptors on T mu- and T gamma-cell subsets was determined according to their capacity to bind different numbers of erythrocyte antibody complexes EAM or EAG [5].
 

Associations of KCNH1 with chemical compounds

  • Dofetilide blocked the triply mutated bEAG T432S/A443S/A453S with an IC(50) value of 1.1 microM [2].
 

Analytical, diagnostic and therapeutic context of KCNH1

References

  1. Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Schönherr, R., Mannuzzu, L.M., Isacoff, E.Y., Heinemann, S.H. Neuron (2002) [Pubmed]
  2. Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels. Ficker, E., Jarolimek, W., Brown, A.M. Mol. Pharmacol. (2001) [Pubmed]
  3. Characterization of ether-à-go-go channels present in photoreceptors reveals similarity to IKx, a K+ current in rod inner segments. Frings, S., Brüll, N., Dzeja, C., Angele, A., Hagen, V., Kaupp, U.B., Baumann, A. J. Gen. Physiol. (1998) [Pubmed]
  4. The role of volatile semiochemicals in mediating host location and selection by nuisance and disease-transmitting cattle flies. Birkett, M.A., Agelopoulos, N., Jensen, K.M., Jespersen, J.B., Pickett, J.A., Prijs, H.J., Thomas, G., Trapman, J.J., Wadhams, L.J., Woodcock, C.M. Med. Vet. Entomol. (2004) [Pubmed]
  5. T mu- and T gamma-cell subsets in normal and leukemic cattle. Surovas, V., Pieskus, J., Tamosiunas, V., Sadauskas, P. Thymus (1982) [Pubmed]
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