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Gene Review:

KRT10 - keratin 10

Bos taurus

Rieger, M. et al., Auewarakul, P. et al., Hassan, A.B. et al., Marsh, I.B. et al., Hendry, K.A. et al., et al.

Hassan, Howell, Hendry, MacCallum, Knight, Wilde,

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Disease relevance of KRT10

RDA3 (206bp) was similar to several sequences in the incomplete genome sequences of M. avium subsp. paratuberculosis K10 and M. avium subsp. avium 104 [1].

High impact information on KRT10

The introns and the 5' upstream regions of the cytokeratin VIb gene do not display notable sequence homologies with the other IF protein genes, but sequences identical with--or very similar to--certain viral and immunoglobulin enhancers have been identified.(ABSTRACT TRUNCATED AT 250 WORDS)[2]
To explore their effects on differentiating epithelial cells in vivo, we used a bovine cytokeratin 10 (K10) promoter to target the expression of E6 and E7 to the suprabasal layers of the epidermis of transgenic mice [3].
Mice that express excess IGF-II delivered using a bovine keratin 10 promoter (k10Igf2/+) develop a disproportionate overgrowth of colon, uterus, and skin [4].
In explant cultures of nasal mucosa of pigs, replication of N-CKIV and N-CKVIb was not markedly reduced in the epithelium [5].
CK5/6 and CK14 were shown by immunohistochemistry to be present in the basal epidermis of healthy tissue, whereas CK10 was found in supra-basal layers [6].

References

Deletion of an mmpL gene and multiple associated genes from the genome of the S strain of Mycobacterium avium subsp. paratuberculosis identified by representational difference analysis and in silico analysis. Marsh, I.B., Whittington, R.J. Mol. Cell. Probes (2005) [Pubmed]
Complete sequence of a bovine type I cytokeratin gene: conserved and variable intron positions in genes of polypeptides of the same cytokeratin subfamily. Rieger, M., Jorcano, J.L., Franke, W.W. EMBO J. (1985) [Pubmed]
Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors. Auewarakul, P., Gissmann, L., Cid-Arregui, A. Mol. Cell. Biol. (1994) [Pubmed]
Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice. Hassan, A.B., Howell, J.A. Cancer Res. (2000) [Pubmed]
Construction and properties of pseudorabies virus recombinants with altered control of immediate-early gene expression. Glazenburg, K.L., Peeters, B.P., Pol, J.M., Gielkens, A.L., Moormann, R.J. J. Virol. (1995) [Pubmed]
Synthesis and distribution of cytokeratins in healthy and ulcerated bovine claw epidermis. Hendry, K.A., MacCallum, A.J., Knight, C.H., Wilde, C.J. J. Dairy Res. (2001) [Pubmed]

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