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PSMB8  -  proteasome (prosome, macropain) subunit,...

Bos taurus

 
 
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High impact information on PSMB8

  • Preincubation with two peptidyl aledhyde inhibitors of the ChT-L activity protected the X subunit in the pituitary MPC and unexpectedly the LMP2 subunit in the spleen MPC from label incorporation, despite the greater amino acid sequence homology of the LMP7 subunit to that of the X subunit [1].
  • Tumor necrosis factor alpha alone and in the presence of LH and/or prostaglandin F2alpha elevated steady-state amounts of LMP10 mRNA but did not affect LMP7 mRNA in cultured luteal cells [2].
  • Expression and regulation of interferon gamma-inducible proteasomal subunits LMP7 and LMP10 in the bovine corpus luteum [2].
  • Thymus proteasome is characterized by the presence of LMP2, LMP7, and LMP10 (MECL1) subunits, which replace the X, Y, and Z subunits [3].
  • We found that the classic class II genes BoLA- DQA, -DQB, -DRA, and -DRB3 are located at BTA 23q21 and the non-classic class II genes DYA, DIB, LMP2, LMP7, TAP2, BoLA-DOB, -DMA, -DMB, and -DNA are located at BTA 23q12-->q13 [4].

References

  1. Reactions of [14C]-3,4-dichloroisocoumarin with subunits of pituitary and spleen multicatalytic proteinase complexes (proteasomes). Orlowski, M., Cardozo, C., Eleuteri, A.M., Kohanski, R., Kam, C.M., Powers, J.C. Biochemistry (1997) [Pubmed]
  2. Expression and regulation of interferon gamma-inducible proteasomal subunits LMP7 and LMP10 in the bovine corpus luteum. Cannon, M.J., Pate, J.L. Biol. Reprod. (2003) [Pubmed]
  3. Isolation and characterization of bovine thymus multicatalytic proteinase complex. Eleuteri, A.M., Angeletti, M., Lupidi, G., Tacconi, R., Bini, L., Fioretti, E. Protein Expr. Purif. (2000) [Pubmed]
  4. Physical assignment of the bovine MHC class IIa and class IIb genes. Hess, M., Goldammer, T., Gelhaus, A., Ried, K., Rappold, G., Eggen, A., Bishop, M.D., Schwerin, M., Horstmann, R.D. Cytogenet. Cell Genet. (1999) [Pubmed]
 
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