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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TRPC4  -  transient receptor potential cation...

Bos taurus

 
 
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High impact information on TRPC4

  • The ability of thapsigargin to increase [Ca(2+)](i) could be due to depletion of Ca(2+) in the acrosome, resulting in the opening of a capacitative calcium entry channel in the plasma membrane [1].
  • By means of a RT-PCR approach, we have found that, in addition to TRPC1, only TRPC4 is expressed, both at the mRNA and protein level, as confirmed by immunoblotting and immunocytochemical analysis [2].
  • Taken together, these results show that TRPC4 protein is expressed in the bovine corneal endothelial cells and may be a negative regulator in ROC stimulated by purinergic activation, but not by store depletion itself [3].
 

Analytical, diagnostic and therapeutic context of TRPC4

References

  1. Intracellular Ca(2+)-Mg(2+)-ATPase regulates calcium influx and acrosomal exocytosis in bull and ram spermatozoa. Dragileva, E., Rubinstein, S., Breitbart, H. Biol. Reprod. (1999) [Pubmed]
  2. Interaction between TRPC channel subunits in endothelial cells. Antoniotti, S., Pla, A.F., Barral, S., Scalabrino, O., Munaron, L., Lovisolo, D. J. Recept. Signal Transduct. Res. (2006) [Pubmed]
  3. Expression and functional evaluation of transient receptor potential channel 4 in bovine corneal endothelial cells. Xie, Q., Zhang, Y., Cai Sun, X., Zhai, C., Bonanno, J.A. Exp. Eye Res. (2005) [Pubmed]
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