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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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ADAM10  -  ADAM metallopeptidase domain 10

Bos taurus

 
 
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Psychiatry related information on ADAM10

 

High impact information on ADAM10

  • Endogenous alpha-secretase activity was inhibited by a dominant negative form of ADAM 10 with a point mutation in the zinc binding site [2].
  • The proteolytically activated form of ADAM 10 was localized by cell surface biotinylation in the plasma membrane, but the majority of the proenzyme was found in the Golgi [2].
  • Due to the close relationship of the ADAM proteins with snake venom enzymes which have been demonstrated to be type IV collagenases, we investigated whether purified bovine ADAM10 could cleave basement membrane type IV collagen [3].
 

Anatomical context of ADAM10

  • We show here that ADAM10 purified from bovine kidney can cleave a basement membrane collagen type IV preparation as assessed by SDS-PAGE analysis and novel epitope recognition with a specific antibody to type IV collagen [3].

References

  1. Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in mice. Schmitt, U., Hiemke, C., Fahrenholz, F., Schroeder, A. Behav. Brain Res. (2006) [Pubmed]
  2. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., Fahrenholz, F. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  3. The metallo-disintegrin ADAM10 (MADM) from bovine kidney has type IV collagenase activity in vitro. Millichip, M.I., Dallas, D.J., Wu, E., Dale, S., McKie, N. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
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