The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

POU1F1  -  POU class 1 homeobox 1

Bos taurus

Synonyms: Pit-1, Pit1
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on POU1F1

  • Analysis of 1767 bp of the 5' flanking region, with respect to putative regulatory elements, revealed a TATA box, two binding sites for growth hormone factor (GHF1), a GC box (SP1), a thyroid-response element (TRE) and a silencer (SiL) sequence motif [1].
  • Results suggest that transcription of the bGH gene begins at the 8- to 16-cell stage in bovine embryos, possibly under control of the transcription factor, Pit-1, and that RFLP analysis of the bGH gene can be used to determine parental origin of transcripts in early embryonic development [2].
  • Likewise, transcripts for Pit-1 were detected at 2-cell (n = 125), 4-cell (n = 114), 8-cell (n = 56), 12-to-32-cell (n = 32), morulae (n = 68), and blastocyst (n = 14) stages [2].
  • Growth hormone (GH) and the Pit-1 transcription factor have been shown to be involved in the physiological mechanisms related to growth [3].
  • Rapid communication: localization of POU1F1 to bovine, ovine, and caprine 1q21-22 [4].
 

Biological context of POU1F1

 

Anatomical context of POU1F1

 

Analytical, diagnostic and therapeutic context of POU1F1

References

  1. Structure of the growth hormone-encoding gene and its promoter in mice. Das, P., Meyer, L., Seyfert, H.M., Brockmann, G., Schwerin, M. Gene (1996) [Pubmed]
  2. Expression of growth hormone and its transcription factor, Pit-1, in early bovine development. Joudrey, E.M., Lechniak, D., Petrik, J., King, W.A. Mol. Reprod. Dev. (2003) [Pubmed]
  3. Lack of association of GH1 and POU1F1 gene variants with meat production traits in Piemontese cattle. Di Stasio, L., Sartore, S., Albera, A. Anim. Genet. (2002) [Pubmed]
  4. Rapid communication: localization of POU1F1 to bovine, ovine, and caprine 1q21-22. Woollard, J., Tuggle, C.K., Ponce de León, F.A. J. Anim. Sci. (2000) [Pubmed]
  5. Ovis aries POU1F1 Gene: Cloning, Characterization and Polymorphism Analysis. Bastos, E., Santos, I., Parmentier, I., Castrillo, J.L., Cravador, A., Guedes-Pinto, H., Renaville, R. Genetica (2006) [Pubmed]
  6. Restriction fragment length polymorphism in amplification products of the bovine PIT1 gene and assignment of PIT1 to bovine chromosome 1. Moody, D.E., Pomp, D., Barendse, W. Anim. Genet. (1995) [Pubmed]
  7. Molecular cloning of the rhesus glycoprotein hormone alpha-subunit gene. Golos, T.G., Durning, M., Fisher, J.M. DNA Cell Biol. (1991) [Pubmed]
  8. Growth hormone and Pit-1 expression in bovine fetal lymphoid cells. Chen, H.T., Schuler, L.A., Schultz, R.D. Domest. Anim. Endocrinol. (1997) [Pubmed]
 
WikiGenes - Universities