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Gene Review

POU1F1  -  POU class 1 homeobox 1

Bos taurus

Synonyms: Pit-1, Pit1
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High impact information on POU1F1

  • Analysis of 1767 bp of the 5' flanking region, with respect to putative regulatory elements, revealed a TATA box, two binding sites for growth hormone factor (GHF1), a GC box (SP1), a thyroid-response element (TRE) and a silencer (SiL) sequence motif [1].
  • Results suggest that transcription of the bGH gene begins at the 8- to 16-cell stage in bovine embryos, possibly under control of the transcription factor, Pit-1, and that RFLP analysis of the bGH gene can be used to determine parental origin of transcripts in early embryonic development [2].
  • Likewise, transcripts for Pit-1 were detected at 2-cell (n = 125), 4-cell (n = 114), 8-cell (n = 56), 12-to-32-cell (n = 32), morulae (n = 68), and blastocyst (n = 14) stages [2].
  • Growth hormone (GH) and the Pit-1 transcription factor have been shown to be involved in the physiological mechanisms related to growth [3].
  • Rapid communication: localization of POU1F1 to bovine, ovine, and caprine 1q21-22 [4].

Biological context of POU1F1


Anatomical context of POU1F1


Analytical, diagnostic and therapeutic context of POU1F1


  1. Structure of the growth hormone-encoding gene and its promoter in mice. Das, P., Meyer, L., Seyfert, H.M., Brockmann, G., Schwerin, M. Gene (1996) [Pubmed]
  2. Expression of growth hormone and its transcription factor, Pit-1, in early bovine development. Joudrey, E.M., Lechniak, D., Petrik, J., King, W.A. Mol. Reprod. Dev. (2003) [Pubmed]
  3. Lack of association of GH1 and POU1F1 gene variants with meat production traits in Piemontese cattle. Di Stasio, L., Sartore, S., Albera, A. Anim. Genet. (2002) [Pubmed]
  4. Rapid communication: localization of POU1F1 to bovine, ovine, and caprine 1q21-22. Woollard, J., Tuggle, C.K., Ponce de León, F.A. J. Anim. Sci. (2000) [Pubmed]
  5. Ovis aries POU1F1 Gene: Cloning, Characterization and Polymorphism Analysis. Bastos, E., Santos, I., Parmentier, I., Castrillo, J.L., Cravador, A., Guedes-Pinto, H., Renaville, R. Genetica (2006) [Pubmed]
  6. Restriction fragment length polymorphism in amplification products of the bovine PIT1 gene and assignment of PIT1 to bovine chromosome 1. Moody, D.E., Pomp, D., Barendse, W. Anim. Genet. (1995) [Pubmed]
  7. Molecular cloning of the rhesus glycoprotein hormone alpha-subunit gene. Golos, T.G., Durning, M., Fisher, J.M. DNA Cell Biol. (1991) [Pubmed]
  8. Growth hormone and Pit-1 expression in bovine fetal lymphoid cells. Chen, H.T., Schuler, L.A., Schultz, R.D. Domest. Anim. Endocrinol. (1997) [Pubmed]
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