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Gene Review

POU5F1  -  POU class 5 homeobox 1

Bos taurus

Synonyms: OCT3, OCT4
 
 
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Disease relevance of POU5F1

 

High impact information on POU5F1

  • Immunohistochemically, staining for the octamer-binding transcription factor 4 (OCT4, also known as POU5F1), revealed a specific and exclusive staining of nuclei of the complete epiblast [2].
  • Oct4 transcript is ubiquitously present in all cells of embryos at the morula stage; however, in Day 7 bovine blastocysts, Oct4 signal is not visible in the trophectoderm by in situ hybridization, indicating that transcriptional downregulation of Oct4 on differentiation is similar to that observed in mouse and other mammals [3].
  • We analyze the temporal and spatial distribution of Oct4 transcript in bovine oocytes and preimplantation-stage embryos, and in contrast to protein distribution, we find strong conservation between bovine and mouse [3].
  • Similar to mouse, bovine Oct4 transcription begins one to two cell cycles after zygotic genome activation, followed by a sharp increase in transcription subsequent to compaction [3].
  • Despite highly conserved genomic organization and regulatory regions between the mouse Oct4 gene and its bovine orthologue, bovine Oct4 protein is not restricted to the inner cell mass of blastocyst-stage embryos, suggesting that Oct4 may not be a key regulator of pluripotency in the bovine [3].
 

Biological context of POU5F1

 

Anatomical context of POU5F1

 

Analytical, diagnostic and therapeutic context of POU5F1

References

  1. Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. Katoh, Y., Katoh, M. Int. J. Oncol. (2007) [Pubmed]
  2. Ultrastructural and immunohistochemical characterization of the bovine epiblast. Vejlsted, M., Avery, B., Schmidt, M., Greve, T., Alexopoulos, N., Maddox-Hyttel, P. Biol. Reprod. (2005) [Pubmed]
  3. Pluripotent lineage definition in bovine embryos by Oct4 transcript localization. Kurosaka, S., Eckardt, S., McLaughlin, K.J. Biol. Reprod. (2004) [Pubmed]
  4. Epigenetic characterization of the CpG islands of bovine Leptin and POU5F1 genes in cloned bovine fetuses. Kremenskoy, M., Kremenska, Y., Suzuki, M., Imai, K., Takahashi, S., Hashizume, K., Yagi, S., Shiota, K. J. Reprod. Dev. (2006) [Pubmed]
  5. Molecular cloning, genetic mapping, and developmental expression of bovine POU5F1. van Eijk, M.J., van Rooijen, M.A., Modina, S., Scesi, L., Folkers, G., van Tol, H.T., Bevers, M.M., Fisher, S.R., Lewin, H.A., Rakacolli, D., Galli, C., de Vaureix, C., Trounson, A.O., Mummery, C.L., Gandolfi, F. Biol. Reprod. (1999) [Pubmed]
 
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