Gene Review:
PPP3R1 - protein phosphatase 3, regulatory subunit...
Bos taurus
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High impact information on PPP3R1
- Calcineurin (CN) is a Ca(2+)/calmodulin(CaM)-dependent serine/threonine protein phosphatase which is a heterodimer composed of a 61 kDa catalytic subunit (CNA) and a 19 kDa regulatory subunit (CNB) [1].
- It was still activated by Ca(2+)/calmodulin but was not regulated by extra CNB and was still strongly stimulated by Mn(2+) and Ni(2+) divalent metal ions [1].
- Its crystal structure reveals that the C-terminal of CNB lies in close vicinity of the N-terminal of CNA and each end has a long arm not involved in the active site [1].
References
- Function and structure of recombinant single chain calcineurin. Qin, Y.L., Yu, D.Y., Wei, Q. Biochem. Biophys. Res. Commun. (2003) [Pubmed]
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