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Gene Review:

BOLA-DYB - major histocompatibility complex, class II...

Bos taurus

Synonyms: Bola-DIB, DYB

Ballingall, K.T. et al., Ballingall, K.T. et al.

Ballingall, Ellis, MacHugh, Archibald, McKeever,

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High impact information on BOLA-DYB

Accepted nomenclature convention suggests that BoLA-DIB should therefore be renamed BoLA-DYB [1].
Analysis of the first full-length DYA and DYB transcripts revealed open reading frames with potential to translate 253 and 259 amino acid proteins, respectively [1].
The major histocompatibility complex (MHC) in ruminants contains a unique pair of class II genes (DYA and DYB) of unknown function [2].

References

The DY genes of the cattle MHC: expression and comparative analysis of an unusual class II MHC gene pair. Ballingall, K.T., Ellis, S.A., MacHugh, N.D., Archibald, S.D., McKeever, D.J. Immunogenetics (2004) [Pubmed]
Conservation of promoter, coding and intronic regions of the non-classical MHC class II DYA gene suggests evolution under functional constraints. Ballingall, K.T., McKeever, D.J. Anim. Genet. (2005) [Pubmed]

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