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GABARAPL2  -  GABA(A) receptor-associated protein-like 2

Bos taurus

 
 
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High impact information on GABARAPL2

  • We have cloned a bovine brain cDNA encoding a conserved 117 amino acid polypeptide, denoted Golgi-associated ATPase Enhancer of 16 kDa (GATE-16), that functions as a soluble transport factor [1].
  • Proteins with strong structural similarity but no detectable sequence homology to GATE-16 include Ras effectors that mediate diverse downstream functions, but each interacts with Ras by forming pseudo-continuous beta-sheets [2].
  • Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p [2].
  • The GATE-16 protein participates in intra-Golgi transport and can associate with the N-ethylmaleimide-sensitive fusion protein and with Golgi SNAREs [2].
  • Processing after the C-terminal glycine residue of GABA(A)-RAP and GATE-16 by cellular proteases is essential for covalent attachment to target molecules [3].
 

Biological context of GABARAPL2

  • To our knowledge, the genomes of CP X604 and CP 721 are the first viral RNAs found with cellular sequences encoding GABA(A)-RAP and GATE-16, respectively [3].

References

 
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