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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ARF2  -  ADP-ribosylation factor 2

Bos taurus

 
 
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Disease relevance of ARF2

 

High impact information on ARF2

  • Here we report the sequence, structure, and functional promoter region of the bovine ARF 2 gene, which was facilitated by constructing a composite cDNA [2].
  • The ARF 2 gene, represented in three overlapping genomic clones, spans approximately 20 kilobase pairs with five exons and four introns [2].
  • The ARF 2 cDNA, constructed from a partial cDNA clone and polymerase chain reaction-amplified fragments from reverse-transcribed poly(A)+ RNA, was approximately 2270 base pairs (bp) (minus the poly(A) tail) [2].
  • The fact that the sizes of these mRNAs are similar to those of other ARFs (ARF 1, 1.9 kb; ARF 2, 2.6 kb; ARF 3, approximately 3.8 and 1.3 kb; ARF 4, 1.8 kb) explain the previously observed inconsistencies between the cDNA and ARF-specific oligonucleotide hybridization patterns [3].
  • To explore this possibility, a cyclic AMP-differentiated HL-60 Lambda ZAP library was screened using the bovine ARF 2 cDNA [3].

References

  1. Characterization of recombinant and endogenous ADP-ribosylation factors synthesized in Sf9 insect cells. Kunz, B.C., Muczynski, K.A., Welsh, C.F., Stanley, S.J., Tsai, S.C., Adamik, R., Chang, P.P., Moss, J., Vaughan, M. Biochemistry (1993) [Pubmed]
  2. Characterization of the gene for ADP-ribosylation factor (ARF) 2, a developmentally regulated, selectively expressed member of the ARF family of approximately 20-kDa guanine nucleotide-binding proteins. Serventi, I.M., Cavanaugh, E., Moss, J., Vaughan, M. J. Biol. Chem. (1993) [Pubmed]
  3. Molecular identification of ADP-ribosylation factor mRNAs and their expression in mammalian cells. Tsuchiya, M., Price, S.R., Tsai, S.C., Moss, J., Vaughan, M. J. Biol. Chem. (1991) [Pubmed]
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