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Gene Review:

PAPPA - pregnancy-associated plasma protein A,...

Bos taurus

Sudo, N. et al., Aad, P.Y. et al., Santiago, C.A. et al.

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High impact information on PAPPA

The aims of the present study were to examine the mRNA expressions of IGF-I, IGFR-1 and pregnancy-associated plasma protein-A (PAPP-A) in granulosa cells and theca tissues during bovine follicular development and the effects of follicle-stimulating hormone (FSH) and estradiol (E2) on the expression of these genes in cultured bovine granulosa cells [1].
Real-time RT-PCR quantification of pregnancy-associated plasma protein-A mRNA abundance in bovine granulosa and theca cells: Effects of hormones in vitro [2].
Proteolytic enzymes such as pregnancy-associated plasma protein-A (PAPP-A) degrade IGFBPs and increase bioavailability of IGF-I and -II during follicular development [2].
Pregnancy-associated plasma protein-A and insulin-like growth factor binding protein mRNAs in granulosa cells of dominant and subordinate follicles of preovulatory cattle [3].

References

Insulin-like growth factor-I (IGF-I) system during follicle development in the bovine ovary: Relationship among IGF-I, type 1 IGF receptor (IGFR-1) and pregnancy-associated plasma protein-A (PAPP-A). Sudo, N., Shimizu, T., Kawashima, C., Kaneko, E., Tetsuka, M., Miyamoto, A. Mol. Cell. Endocrinol. (2007) [Pubmed]
Real-time RT-PCR quantification of pregnancy-associated plasma protein-A mRNA abundance in bovine granulosa and theca cells: Effects of hormones in vitro. Aad, P.Y., Voge, J.L., Santiago, C.A., Malayer, J.R., Spicer, L.J. Domest. Anim. Endocrinol. (2006) [Pubmed]
Pregnancy-associated plasma protein-A and insulin-like growth factor binding protein mRNAs in granulosa cells of dominant and subordinate follicles of preovulatory cattle. Santiago, C.A., Voge, J.L., Aad, P.Y., Allen, D.T., Stein, D.R., Malayer, J.R., Spicer, L.J. Domest. Anim. Endocrinol. (2005) [Pubmed]

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PAPPA	Canis lupus familiaris
pappaa	Danio rerio
pappab	Danio rerio
PAPPA	Gallus gallus
PAPPA	Homo sapiens
PAPPA	Macaca mulatta
Pappa	Mus musculus
PAPPA	Pan troglodytes
Pappa	Rattus norvegicus
pappa	Xenopus (Silurana) tropicalis

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