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Atf5  -  activating transcription factor 5

Rattus norvegicus

Synonyms: Activating transcription factor 5, Atfx, Cyclic AMP-dependent transcription factor ATF-5, Transcription factor ATFx, cAMP-dependent transcription factor ATF-5
 
 
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High impact information on Atf5

  • These findings identify ATF5 as a key regulator of astrocyte formation and potentially of the VZ to SVZ transition [1].
  • Constitutive ATF5 expression maintains neural progenitor cell proliferation and blocks their in vitro and in vivo differentiation into astrocytes [1].
  • Conversely, loss of ATF5 function promotes cell-cycle exit and allows astrocytic differentiation in vitro and in vivo [1].
 

Biological context of Atf5

References

  1. Downregulation of activating transcription factor 5 is required for differentiation of neural progenitor cells into astrocytes. Angelastro, J.M., Mason, J.L., Ignatova, T.N., Kukekov, V.G., Stengren, G.B., Goldman, J.E., Greene, L.A. J. Neurosci. (2005) [Pubmed]
 
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