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Gene Review:

micF - ncRNA

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK2208, IS113, JWR0043, stc

Esterling, L. et al., Jin, T. et al., Papamichail, D. et al.

Papamichail, Delihas,

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Disease relevance of micF

Osmoregulation of the porin genes, ompF and ompC of Escherichia coli, occurs at the level of transcription through the action of EnvZ and OmpR proteins as well as at the level of translation through micF antisense RNA [1].
Southern analyses show that the micF gene is present in related Gram-negative bacteria, including Salmonella typhimurium, Klebsiella pneumoniae, and Pseudomonas aeruginosa [2].
DNA sequences from Salmonella typhi, Salmonella typhimurium, and Klebsiella pneumoniae show greater than 96% homology in the micF gene when compared to the Escherichia coli micF sequence [2].
The regulatory RNA gene micF is present in several species of gram-negative bacteria and is phylogenetically conserved [2].

High impact information on micF

In addition, Northern analyses indicate that micF RNA and ompF mRNA levels are thermally regulated in several related species in a manner similar to the thermoregulation in Escherichia coli [2].
Transcripts from these genes are regulated by the small non-coding RNAs micF, micC, and micA, respectively [3].

References

Identification of the genes in multicopy plasmids affecting ompC and ompF expression in Escherichia coli. Jin, T., Inouye, M. FEMS Microbiol. Lett. (1995) [Pubmed]
The regulatory RNA gene micF is present in several species of gram-negative bacteria and is phylogenetically conserved. Esterling, L., Delihas, N. Mol. Microbiol. (1994) [Pubmed]
Outer membrane protein genes and their small non-coding RNA regulator genes in Photorhabdus luminescens. Papamichail, D., Delihas, N. Biology direct [electronic resource]. (2006) [Pubmed]

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