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Gene Review:

MFAP4 - microfibrillar-associated protein 4

Bos taurus

Watanabe, Y. et al., Kobayashi, R. et al., Asai, M. et al.

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High impact information on MFAP4

Solid-phase binding assays indicated a preferential affinity of native calvasculin for 36-kDa MAP among the extracellular matrices in a Ca(2+)-dependent manner [1].
These results suggest that calvasculin, intracellular Ca(2+)-binding protein, is released to the extracellular space and binds with 36-kDa MAP [1].
This protein bound with an extracellular matrix protein, 36-kDa microfibril-associated glycoprotein (36-kDa MAP), in a Ca(2+)-dependent manner in vitro [1].
Partial amino acid sequence of 36-kDa MAP was determined [2].
ALOX12 and MFAP4 were the closest genes proximal and distal, respectively, to the scurs locus [3].

Analytical, diagnostic and therapeutic context of MFAP4

Using Ca(2+)-dependent affinity chromatography on an isoquinolinesulfonamide derivative (CKA-1303)-coupled Sepharose, we obtained a pure form of 36-kDa MAP [2].

References

Calvasculin, an encoded protein from mRNA termed pEL-98, 18A2, 42A, or p9Ka, is secreted by smooth muscle cells in culture and exhibits Ca(2+)-dependent binding to 36-kDa microfibril-associated glycoprotein. Watanabe, Y., Usuda, N., Tsugane, S., Kobayashi, R., Hidaka, H. J. Biol. Chem. (1992) [Pubmed]
Isolation and characterization of a 36-kDa microfibril-associated glycoprotein by the newly synthesized isoquinolinesulfonamide affinity chromatography. Kobayashi, R., Mizutani, A., Hidaka, H. Biochem. Biophys. Res. Commun. (1994) [Pubmed]
The scurs locus in cattle maps to bovine chromosome 19. Asai, M., Berryere, T.G., Schmutz, S.M. Anim. Genet. (2004) [Pubmed]

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AgaP_AGAP007031	Anopheles gambiae str. PEST
MFAP4	Canis lupus familiaris
sca	Drosophila melanogaster
MFAP4	Homo sapiens
Mfap4	Mus musculus
Mfap4	Rattus norvegicus
LOC100488644	Xenopus (Silurana) tropicalis
LOC100488329	Xenopus (Silurana) tropicalis

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