Disease relevance of Rars_predicted

• In a wide spectrum of hepatomas of different growth rates, a significant increase of 1.4-2.4-fold in arginyl-tRNA synthetase activity was observed when compared with that of liver of control normal rats [1].

High impact information on Rars_predicted

• A basic NH2-terminal extension of rat liver arginyl-tRNA synthetase required for its association with high molecular weight complexes [2].
• Removal of lipids from the complex with the nonionic detergent, Triton X-114, rendered arginyl-tRNA synthetase sensitive to the addition of NaCl [3].
• It is shown that irrespective of the addition or not of several proteinase inhibitors, lysyl-tRNA synthetase was present exclusively as a high-Mr entity, while arginyl-tRNA synthetase occurred as high- and low-Mr forms, in the constant proportions of 2:1, respectively [4].
• 0. Taking the hepatic specific activity for arginyl-tRNA synthetase as 100%, deep layer of gut, thymus and testis had higher activity; renal cortex and spleen had the same activity; and skeletal muscle, brain, heart, lung, superficial layer of gut and adipose tissue had lower activity [1].

Associations of Rars_predicted with chemical compounds

• These results demonstrate directly that the complex-derived and free forms of arginyl-tRNA synthetase are closely related proteins, but that the former includes a basic, NH2-terminal extension absent in the free form [2].

References