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Acbd3  -  acyl-CoA binding domain containing 3

Rattus norvegicus

Synonyms: Acyl-CoA-binding domain-containing protein 3, DAP, DMT1-associated protein, GOCAP1, GOLPH1, ...
 
 
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Psychiatry related information on Acbd3

 

High impact information on Acbd3

  • Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons [2].
  • Previous studies have shown that inhibition of a Golgi-complex-associated lysophospholipid acyltransferase (LPAT) activity by the drug CI-976 stimulates Golgi tubule formation and subsequent redistribution of resident Golgi proteins to the endoplasmic reticulum (ER) [3].
  • Seizures caused a small decline in levels of the approximately 160-kD DAP kinase within injured ipsilateral hippocampus, commensurate with the appearance of an approximately 60-kD fragment, and proteolysis of the p53 inhibitor, murine double minute gene 2 (MDM2) [4].
  • Death-associated protein (DAP) kinase is a novel regulator of cell death whose in vivo target(s) and role in neuronal cell death remain uncertain [4].
  • On exposure of PC12 cells to 30 microm C(2)-ceramide, both the total (assayed in the presence of Ca(2+)/calmodulin) and Ca(2+)/calmodulin-independent (assayed in the presence of EGTA) DAP kinase activities were transiently increased 5.0- and 12.2-fold, respectively, at 10 min, and then decreased to 1.7- and 3.4-fold at 90 min [5].
 

Biological context of Acbd3

  • DAP transcripts were absent in virgin uteri and during the day of implantation (day 5), low in early gestation tissues (days 8, 9) and high during midgestation (days 10-14) [6].
  • Hemodynamic parameters: systolic, diastolic and mean arterial pressure (SAP, DAP, MAP), heart rate (HR), left ventricular end diastolic pressure (LVEDP), left ventricular peak (+)LVdP/dt and (-)LVdP/dt were monitored [7].
 

Anatomical context of Acbd3

  • In contrast, DAP kinase and MDM2 were not proteolyzed within the seizure damage-resistant contralateral hippocampus [4].
  • DAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cells [5].
  • No signal was observed in granulated metrial gland cells. mRNA encoding DAP was also found in the smooth circular muscle coat adjacent to the mesometrial decidua [6].
  • On day 9, mRNA encoding DAP was found in the same area as on day 8 as well as in the outer layer of cells in the antimesometrial decidua adjacent to the myometrium termed the fibrinoid capsula [6].
 

Associations of Acbd3 with chemical compounds

 

Analytical, diagnostic and therapeutic context of Acbd3

  • The patterns of expression of mRNA encoding decidualization-associated protein (DAP) in the rat uterus from early, mid-, and late stages of pregnancy were examined by in situ hybridization to provide an insight into the function of DAP during pregnancy [6].

References

  1. Non-symmetrical double-logistic analysis of 24-h blood pressure recordings in normotensive and hypertensive rats. Head, G.A., Lukoshkova, E.V., Mayorov, D.N., van den Buuse, M. J. Hypertens. (2004) [Pubmed]
  2. Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons. Pelled, D., Raveh, T., Riebeling, C., Fridkin, M., Berissi, H., Futerman, A.H., Kimchi, A. J. Biol. Chem. (2002) [Pubmed]
  3. A unique lysophospholipid acyltransferase (LPAT) antagonist, CI-976, affects secretory and endocytic membrane trafficking pathways. Chambers, K., Judson, B., Brown, W.J. J. Cell. Sci. (2005) [Pubmed]
  4. Expression, interaction, and proteolysis of death-associated protein kinase and p53 within vulnerable and resistant hippocampal subfields following seizures. Araki, T., Shinoda, S., Schindler, C.K., Quan-Lan, J., Meller, R., Taki, W., Simon, R.P., Henshall, D.C. Hippocampus. (2004) [Pubmed]
  5. DAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cells. Yamamoto, M., Hioki, T., Ishii, T., Nakajima-Iijima, S., Uchino, S. Eur. J. Biochem. (2002) [Pubmed]
  6. Expression of mRNA encoding decidualization-associated protein, a variant of acute-phase alpha 2 macroglobulin, by rat uterine tissues during pregnancy and pseudopregnancy. da Silva, G.C., Teixeira, N., Pringle, J.H., Bell, S.C. J. Reprod. Fertil. (1996) [Pubmed]
  7. Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment. Gupta, S.K., Mohanty, I., Talwar, K.K., Dinda, A., Joshi, S., Bansal, P., Saxena, A., Arya, D.S. Mol. Cell. Biochem. (2004) [Pubmed]
  8. A new polyamine derivative, a structural analog of spermine, with in vivo activity as an inhibitor of ethanol appetite. Font, M., Sanmartín, C., García, H., Contreras, S., Paeile, C., Bilbeny, N. Bioorg. Med. Chem. (2005) [Pubmed]
  9. Interaction of 2,4-diaminopyridine with cholinesterase inhibitors. Biessels, P.T., Houwertjes, M.C., Agoston, S., Horn, A.S. Archives internationales de pharmacodynamie et de thérapie. (1988) [Pubmed]
 
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