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Gene Review

Snn  -  stannin

Rattus norvegicus

Synonyms: Stannin
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Disease relevance of Snn


High impact information on Snn


Biological context of Snn


Physical interactions of Snn


Regulatory relationships of Snn

  • In addition, we present the evidence that Snn overexpression results in reduced extracellular regulated kinase activation and increased p38 activation [1].

Other interactions of Snn

  • Together, these findings indicate a role of Snn in modulation of MAPK signaling pathways through its interactions with 14-3-3zeta [1].
  • In contrast, the activity of c-Jun N-terminal kinase did not change following Snn overexpression [1].


  1. The protein stannin binds 14-3-3zeta and modulates mitogen-activated protein kinase signaling. Davidson, C.E., Reese, B.E., Billingsley, M.L., Yun, J.K. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  2. Induction of apoptosis by organotin compounds in vitro: neuronal protection with antisense oligonucleotides directed against stannin. Thompson, T.A., Lewis, J.M., Dejneka, N.S., Severs, W.B., Polavarapu, R., Billingsley, M.L. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  3. Alterations in hippocampal expression of SNAP-25, GAP-43, stannin and glial fibrillary acidic protein following mechanical and trimethyltin-induced injury in the rat. Patanow, C.M., Day, J.R., Billingsley, M.L. Neuroscience (1997) [Pubmed]
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