High impact information on Jag2

• Early after birth, Jag2 expression decreased in hair cells while the pattern of Notch1 expression now included both supporting cells and hair cells [1].
• Jagged2: a serrate-like gene expressed during rat embryogenesis [2].
• In contrast to previously described DSL ligands for Notch, Jagged2 is not widely expressed in the developing central nervous system [2].
• Using specific HC markers, i.e. jagged2 (Jag2) and Math1, we showed that in addition to existing OHCs, supernumerary OHCs, tectal cells and Hensen's cells expressed these markers in embryonic day 19 organ of Corti explants after 5 days in vitro [3].
• Here, we examined the expression pattern of four Delta, Serrate and Lag-2 (DSL) ligands, Jagged1, Jagged2, Delta-like1 (Dl1) and Delta-like 3 (Dl3), in late embryonic and postnatal rat brain by in situ hybridization [4].

Anatomical context of Jag2

• Jagged2 mRNA was transiently expressed in cerebral blood vessels and choroid plexus during the first postnatal week [4].
• Expression of Notch1 and Jagged2 in the enteric nervous system [5].
• In the enteric nervous system, Notch1 and Jagged2 were expressed in ganglia of the submucosal and myenteric plexus [5].
• On the other hand, the strong signal of DeltaNp63 mRNA was already recognized in the vas deferens at day 0 after birth and advanced chronologically along the duct to the caput epididymis and p63 protein was expressed in basal cells in their epithelium, whereas the mRNAs of Jagged 2 and Notch 1 were maintained at a low level [6].

References