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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Nutf2  -  nuclear transport factor 2

Rattus norvegicus

Synonyms: NTF-2, Ntf2, Nuclear transport factor 2
 
 
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Disease relevance of NTF2

 

High impact information on NTF2

  • We have used a range of complementary biochemical and biophysical methods to investigate the interactions between nuclear transport factor 2 (NTF2), the Ras family GTPase Ran, and XFXFG nucleoporin repeats that are crucial for nuclear trafficking [2].
  • T42A-Ran.GDP also retains the ability to bind p10/NTF2, a component of the nuclear import pathway [3].
  • The NTF2 polypeptide chain forms an alpha + beta barrel that opens at one end to form a distinctive hydrophobic cavity and its fold is homologous to that of scytalone dehydratase [4].
 

Biological context of NTF2

  • The NTF2 hydrophobic cavity is a candidate for a potential binding site for other proteins involved in nuclear import such as Ran and nucleoporin p62 [4].
 

Analytical, diagnostic and therapeutic context of NTF2

  • We have determined the structure of bacterially expressed rat NTF2 at 1.6 angstroms resolution using X-ray crystallography [4].
  • We used three complementary NMR methods, namely amide group chemical shift titrations, NOE and cross-saturation measurements, to show that the major FxFG-binding site on the dimeric rat NTF2 (rNTF2) molecule is centred on Trp7 and is formed by residues from both NTF2 chains [5].
  • Crystallization and preliminary X-ray diffraction analysis of nuclear transport factor 2 [1].

References

  1. Crystallization and preliminary X-ray diffraction analysis of nuclear transport factor 2. Kent, H.M., Clarkson, W.D., Bullock, T.L., Stewart, M. J. Struct. Biol. (1996) [Pubmed]
  2. Dissecting the interactions between NTF2, RanGDP, and the nucleoporin XFXFG repeats. Chaillan-Huntington, C., Braslavsky, C.V., Kuhlmann, J., Stewart, M. J. Biol. Chem. (2000) [Pubmed]
  3. A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import. Murphy, G.A., Moore, M.S., Drivas, G., Pérez de la Ossa, P., Villamarin, A., D'Eustachio, P., Rush, M.G. Mol. Biol. Cell (1997) [Pubmed]
  4. The 1.6 angstroms resolution crystal structure of nuclear transport factor 2 (NTF2). Bullock, T.L., Clarkson, W.D., Kent, H.M., Stewart, M. J. Mol. Biol. (1996) [Pubmed]
  5. Solution NMR study of the interaction between NTF2 and nucleoporin FxFG repeats. Morrison, J., Yang, J.C., Stewart, M., Neuhaus, D. J. Mol. Biol. (2003) [Pubmed]
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