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Gene Review:

Irf8 - interferon regulatory factor 8

Rattus norvegicus

Synonyms: ICSBP, Icsbp1

Nakano, N. et al.

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High impact information on Irf8

We isolated cDNA encoding a full-length Interferon (IFN) consensus sequence binding protein [Icsbp; also called IFN regulatory factor-8 (Irf-8)] from rat and analyzed interaction between ICSBP and PU.1, an Ets-family transcription factor regulating hematopoietic cell-specific promoters [1].
These results indicated that Ser147 of PU.1 is definitively required for forming a complex with ICSBP and phosphorylation of PU.1 and/or ICSBP is critical for formation of the ternary complex [1].

Analytical, diagnostic and therapeutic context of Irf8

Electrophoretic mobility shift assay indicated that PU.1 with deletion of the PEST domain could not bind to ICSBP, although loss of the PEST domain had no effect on DNA-binding ability of PU.1 itself [1].
Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: molecular cloning of rat Icsbp (Irf-8) cDNA [1].

References

Analysis of PU.1/ICSBP (IRF-8) complex formation with various PU.1 mutants: molecular cloning of rat Icsbp (Irf-8) cDNA. Nakano, N., Nishiyama, C., Masuoka, N., Nishiyama, M., Yamane, H., Okumura, K., Ogawa, H. Immunogenetics (2005) [Pubmed]

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