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Gene Review:

Stmn3 - stathmin-like 3

Rattus norvegicus

Synonyms: SCG10-like protein, Sclip, Stathmin-3

Kang, S.W. et al., Nakazawa, T. et al., Ozon, S. et al.

Ozon, El Mestikawy, Sobel,

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Disease relevance of Stmn3

The SCG10-related gene family in the developing rat retina: persistent expression of SCLIP and stathmin in mature ganglion cell layer [1].

High impact information on Stmn3

Taken together, these results suggest that the clusterin interacts with SCLIP and the interaction may act as an important modulator during neuronal differentiation [2].
In this study, we show that clusterin interacts with the microtubule-destabilizing stathmin family protein SCLIP by GST pull-down and co-immunoprecipitation assays [2].
In addition, we show that the minimal domains for the interaction are mapped to the C-terminal valine-rich region (367-447) of clusterin and the N-terminal palmitoylation and membrane attachment site (1-34) of SCLIP [2].
At a regional level, SCG10 and SCLIP appear generally distributed similarly except in a few areas [3].
In the postnatal retina, the level of SCLIP increased, whereas the level of RB3 remained low [1].

Anatomical context of Stmn3

Both clusterin and SCLIP are co-localized at the perinuclear region and growth cone of PC12 cells [2].
Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells [2].

References

The SCG10-related gene family in the developing rat retina: persistent expression of SCLIP and stathmin in mature ganglion cell layer. Nakazawa, T., Nakano, I., Furuyama, T., Morii, H., Tamai, M., Mori, N. Brain Res. (2000) [Pubmed]
Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells. Kang, S.W., Shin, Y.J., Shim, Y.J., Jeong, S.Y., Park, I.S., Min, B.H. Exp. Cell Res. (2005) [Pubmed]
Differential, regional, and cellular expression of the stathmin family transcripts in the adult rat brain. Ozon, S., El Mestikawy, S., Sobel, A. J. Neurosci. Res. (1999) [Pubmed]

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stmn3	Danio rerio
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STMN3	Homo sapiens
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