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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cyp2c7  -  cytochrome P450, family 2, subfamily c,...

Rattus norvegicus

Synonyms: CYPIIC7, Cyp2c-7, Cytochrome P450 2C7, Cytochrome P450F, PTF1
 
 
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Disease relevance of Cyp2c7

  • This site-directed UV cross-linking shows that PTF1 contains two DNA-binding proteins, distinct in size and sensitivity to Staphylococcus aureus V8 protease [1].
 

High impact information on Cyp2c7

  • The cognate sequence of transcription factor PTF1, which plays a key role in pancreas-specific gene expression, has a bipartite organization [1].
  • Sequence studies also revealed that these two elements differ from the previously identified recognition sequence for pancreas transcription factor 1 (PTF1) [2].
  • In addition, polyspecific antibody to the rat cytochrome P450 2C subfamily gave several immunostained protein bands, but antibodies specific to rat cytochrome P450 2C7 and 2C13 did not react, while antibody specific to cytochrome P450 2C11 yielded an ambiguous result [3].
  • Neonatal testosterone treatment also increased hepatic cytochrome P450 2C7 content in both ovariectomized females and intact males [4].
  • Furthermore, neonatal and/or pubertal administration of estradiol to intact male rats induced cytochrome P450 2C7 to adult female levels [4].

References

  1. The cell-specific transcription factor PTF1 contains two different subunits that interact with the DNA. Roux, E., Strubin, M., Hagenbüchle, O., Wellauer, P.K. Genes Dev. (1989) [Pubmed]
  2. Identification of novel pancreas-specific regulatory sequences in the promoter region of human pancreatic secretory trypsin inhibitor gene. Yasuda, T., Yasuda, T., Ohmachi, Y., Katsuki, M., Yokoyama, M., Murata, A., Monden, M., Matsubara, K. J. Biol. Chem. (1998) [Pubmed]
  3. Catalytic and immunologic characterization of hepatic and lung cytochromes P450 in the polar bear. Bandiera, S.M., Torok, S.M., Lin, S., Ramsay, M.A., Norstrom, R.J. Biochem. Pharmacol. (1995) [Pubmed]
  4. Effects of testosterone and estrogen on hepatic levels of cytochromes P450 2C7 and P450 2C11 in the rat. Bandiera, S., Dworschak, C. Arch. Biochem. Biophys. (1992) [Pubmed]
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