The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Fgf7  -  fibroblast growth factor 7

Rattus norvegicus

Synonyms: FGF-7, Fgf-7, Fibroblast growth factor 7, HBGF-7, Heparin-binding growth factor 7, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Fgf7


High impact information on Fgf7

  • In addition, KGF increased the mRNA levels of the transcription factors CCAAT/enhancer-binding protein alpha (C/EBPalpha) and C/EBPdelta as well as SREBP-1c (ADD-1), but not PPARgamma [5].
  • We developed culture conditions in which keratinocyte growth factor (KGF) stimulates fatty acid and phospholipid synthesis [5].
  • In summary, KGF stimulates lipogenesis in type II cells by a coordinated expression of lipogenic enzymes and transport proteins regulated by C/EBP isoforms and SREBP-1c [5].
  • KGF stimulated acetate incorporation into phosphatidylcholine, disaturated phosphatidylcholine, and phosphatidylglycerol more than 5% rat serum alone [5].
  • 6 h after administration, immunoreactive KGF was observed within the lung parenchyma and along alveolar epithelial cell membranes [6].

Chemical compound and disease context of Fgf7


Biological context of Fgf7


Anatomical context of Fgf7

  • We hypothesized that KGF may protect the lung not only by inducing proliferation but also by promoting epithelial repair via enhanced epithelial cell migration [16].
  • KGF reduced cytoskeleton stiffness as measured by magnetic twisting cytometry and increased cell motility (5.8 +/- 0.42 microm/h with KGF vs 3.7 +/- 0.41 microm/h in controls) [16].
  • KGF acted primarily by inducing lamellipodia emission (73.2 +/- 3.9% of KGF-treated cells had lamellipodia vs 61.3 +/- 3.4% of control cells) and increasing their relative surface area (59 +/- 2.7% with KGF vs 48 +/- 2.0% in controls) [16].
  • To further delineate KGF properties as a mesenchymal mediator, we wondered about its possibility to relay glucocorticoid-stimulating activity on the synthesis of the phospholipid moiety of surfactant in fetal lung fibroblasts [17].
  • Here, we investigated, among the factors produced by lung mesenchyme, the part attributable to KGF in the control of surfactant synthesis [17].

Associations of Fgf7 with chemical compounds


Regulatory relationships of Fgf7


Other interactions of Fgf7


Analytical, diagnostic and therapeutic context of Fgf7


  1. Differential distribution of fibroblast growth factor (FGF)-7 and FGF-10 in L-arginine-induced acute pancreatitis. Ishiwata, T., Naito, Z., Lu, Y.P., Kawahara, K., Fujii, T., Kawamoto, Y., Teduka, K., Sugisaki, Y. Exp. Mol. Pathol. (2002) [Pubmed]
  2. Transforming growth factor-beta antagonizes alveolar type II cell proliferation induced by keratinocyte growth factor. Zhang, F., Nielsen, L.D., Lucas, J.J., Mason, R.J. Am. J. Respir. Cell Mol. Biol. (2004) [Pubmed]
  3. Keratinocyte growth factor can enhance alveolar epithelial repair by nonmitogenic mechanisms. Atabai, K., Ishigaki, M., Geiser, T., Ueki, I., Matthay, M.A., Ware, L.B. Am. J. Physiol. Lung Cell Mol. Physiol. (2002) [Pubmed]
  4. Growth factor expression in the obstructed developing and mature rat kidney. Nguyen, H.T., Thomson, A.A., Kogan, B.A., Baskin, L.S., Cunha, G.R. Lab. Invest. (1999) [Pubmed]
  5. Keratinocyte growth factor and the transcription factors C/EBP alpha, C/EBP delta, and SREBP-1c regulate fatty acid synthesis in alveolar type II cells. Mason, R.J., Pan, T., Edeen, K.E., Nielsen, L.D., Zhang, F., Longphre, M., Eckart, M.R., Neben, S. J. Clin. Invest. (2003) [Pubmed]
  6. Intratracheal instillation of keratinocyte growth factor decreases hyperoxia-induced mortality in rats. Panos, R.J., Bak, P.M., Simonet, W.S., Rubin, J.S., Smith, L.J. J. Clin. Invest. (1995) [Pubmed]
  7. Keratinocyte growth factor decreases pulmonary edema, transforming growth factor-beta and platelet-derived growth factor-BB expression, and alveolar type II cell loss in bleomycin-induced lung injury. Yi, E.S., Salgado, M., Williams, S., Kim, S.J., Masliah, E., Yin, S., Ulich, T.R. Inflammation (1998) [Pubmed]
  8. Keratinocyte growth factor ameliorates mucosal injury in an experimental model of colitis in rats. Zeeh, J.M., Procaccino, F., Hoffmann, P., Aukerman, S.L., McRoberts, J.A., Soltani, S., Pierce, G.F., Lakshmanan, J., Lacey, D., Eysselein, V.E. Gastroenterology (1996) [Pubmed]
  9. Keratinocyte growth factor ameliorates cyclophosphamide-induced ulcerative hemorrhagic cystitis. Ulich, T.R., Whitcomb, L., Tang, W., O'Conner Tressel, P., Tarpley, J., Yi, E.S., Lacey, D. Cancer Res. (1997) [Pubmed]
  10. Keratinocyte growth factor prevents ventilator-induced lung injury in an ex vivo rat model. Welsh, D.A., Summer, W.R., Dobard, E.P., Nelson, S., Mason, C.M. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  11. Keratinocyte growth factor increases transalveolar sodium reabsorption in normal and injured rat lungs. Guery, B.P., Mason, C.M., Dobard, E.P., Beaucaire, G., Summer, W.R., Nelson, S. Am. J. Respir. Crit. Care Med. (1997) [Pubmed]
  12. Keratinocyte growth factor stimulates migration and hyaluronan synthesis in the epidermis by activation of keratinocyte hyaluronan synthases 2 and 3. Karvinen, S., Pasonen-Seppänen, S., Hyttinen, J.M., Pienimäki, J.P., Törrönen, K., Jokela, T.A., Tammi, M.I., Tammi, R. J. Biol. Chem. (2003) [Pubmed]
  13. Growth factors and receptors in bladder development and obstruction. Baskin, L.S., Sutherland, R.S., Thomson, A.A., Hayward, S.W., Cunha, G.R. Lab. Invest. (1996) [Pubmed]
  14. Effects of aging on growth factors gene and protein expression in the dorsal and ventral lobes of rat prostate. Zhao, H., Patra, A., Yeh, C.C., Tanaka, Y., Oh, B.R., Dahiya, R. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  15. Induction of alveolar type II cell differentiation in embryonic tracheal epithelium in mesenchyme-free culture. Shannon, J.M., Gebb, S.A., Nielsen, L.D. Development (1999) [Pubmed]
  16. Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Galiacy, S., Planus, E., Lepetit, H., Féréol, S., Laurent, V., Ware, L., Isabey, D., Matthay, M., Harf, A., d'Ortho, M.P. Exp. Cell Res. (2003) [Pubmed]
  17. Role of keratinocyte growth factor in the control of surfactant synthesis by fetal lung mesenchyme. Chelly, N., Henrion, A., Pinteur, C., Chailley-Heu, B., Bourbon, J.R. Endocrinology (2001) [Pubmed]
  18. Fibroblast growth factor-10. A second candidate stromal to epithelial cell andromedin in prostate. Lu, W., Luo, Y., Kan, M., McKeehan, W.L. J. Biol. Chem. (1999) [Pubmed]
  19. Keratinocyte growth factor induces lipogenesis in alveolar type II cells through a sterol regulatory element binding protein-1c-dependent pathway. Chang, Y., Edeen, K., Lu, X., De Leon, M., Mason, R.J. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  20. Similarities and differences between the effects of heparin and glypican-1 on the bioactivity of acidic fibroblast growth factor and the keratinocyte growth factor. Berman, B., Ostrovsky, O., Shlissel, M., Lang, T., Regan, D., Vlodavsky, I., Ishai-Michaeli, R., Ron, D. J. Biol. Chem. (1999) [Pubmed]
  21. TGF-beta superfamily members modulate growth, branching, shaping, and patterning of the ureteric bud. Bush, K.T., Sakurai, H., Steer, D.L., Leonard, M.O., Sampogna, R.V., Meyer, T.N., Schwesinger, C., Qiao, J., Nigam, S.K. Dev. Biol. (2004) [Pubmed]
  22. Keratinocyte growth factor and embryonic rat lung morphogenesis. Shiratori, M., Oshika, E., Ung, L.P., Singh, G., Shinozuka, H., Warburton, D., Michalopoulos, G., Katyal, S.L. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  23. Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. Ulich, T.R., Yi, E.S., Longmuir, K., Yin, S., Biltz, R., Morris, C.F., Housley, R.M., Pierce, G.F. J. Clin. Invest. (1994) [Pubmed]
WikiGenes - Universities