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Gene Review:

Neurog1 - neurogenin 1

Rattus norvegicus

Synonyms: NGN-1, NeuroD3, Neurod3, Neurogenic basic-helix-loop-helix protein, Neurogenic differentiation factor 3, ...

Ohtsuka, T. et al., Chen, J. et al., Kawai, T. et al., Okuyama, N. et al., Lo, L. et al.

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High impact information on Neurod3

In the vertebrate peripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1 are required for sensory and autonomic neurogenesis, respectively [1].
The neurogenic basic helix-loop-helix transcription factor NeuroD protein in the dentate gyrus after MK-801 treatment was expressed transiently in proliferative cells, but not in mature neurons [2].
DETA-NONOate selectively increased Neurogenin 1 and decreased glial fibrillary acidic protein mRNA expression in retired breeder neurospheres [3].
Regulated expression of neurogenic basic helix-loop-helix transcription factors during differentiation of the immortalized neuronal progenitor cell line HC2S2 into neurons [4].

Anatomical context of Neurod3

These results suggest that an inhibition of Notch activity and subsequent expression of neurogenic basic helix-loop-helix factors, including Mash1, may, at least in part, contribute to ischemia-induced neurogenesis in the adult dentate gyrus [5].

Associations of Neurod3 with chemical compounds

Expression of nine neurogenic basic helix-loop-helix (bHLH) transcription factors was examined in an immortalized neuronal progenitor cell line HC2S2, which differentiates into neurons after suppression of the v-myc expression with tetracycline [4].

References

Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. Lo, L., Dormand, E., Greenwood, A., Anderson, D.J. Development (2002) [Pubmed]
Phosphorylation of extracellular-regulating kinase in NMDA receptor antagonist-induced newly generated neurons in the adult rat dentate gyrus. Okuyama, N., Takagi, N., Kawai, T., Miyake-Takagi, K., Takeo, S. J. Neurochem. (2004) [Pubmed]
N-cadherin mediates nitric oxide-induced neurogenesis in young and retired breeder neurospheres. Chen, J., Zacharek, A., Li, Y., Li, A., Wang, L., Katakowski, M., Roberts, C., Lu, M., Chopp, M. Neuroscience (2006) [Pubmed]
Regulated expression of neurogenic basic helix-loop-helix transcription factors during differentiation of the immortalized neuronal progenitor cell line HC2S2 into neurons. Ohtsuka, T., Asahi, M., Matsuura, N., Kikuchi, H., Hojo, M., Kageyama, R., Ohkubo, H., Hoshimaru, M. Cell Tissue Res. (1998) [Pubmed]
Changes in the expression of Hes5 and Mash1 mRNA in the adult rat dentate gyrus after transient forebrain ischemia. Kawai, T., Takagi, N., Nakahara, M., Takeo, S. Neurosci. Lett. (2005) [Pubmed]

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NEUROG1	Bos taurus
NEUROG1	Canis lupus familiaris
neurog1	Danio rerio
NEUROG1	Gallus gallus
NEUROG1	Homo sapiens
NEUROG1	Macaca mulatta
Neurog1	Mus musculus
NEUROG1	Pan troglodytes
neurog1	Xenopus (Silurana) tropicalis

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