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Gene Review:

Ncr3 - natural cytotoxicity triggering receptor 3

Rattus norvegicus

Synonyms: 1C7, 1c7, NK-p30, NKp30, Natural cytotoxicity triggering receptor 3, ...

Hsieh, C.L. et al., Bäckman-Petersson, E. et al., Hsieh, C.L. et al.

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Disease relevance of Ncr3

Transfection of rat 1C7 into the NK cell line RNK-16 induced cytolytic activity against glioma as well as lymphoma tumor cells [1].

High impact information on Ncr3

Liver NK cells expressed low levels of NKp30 and had reduced rNKp30-mediated IFN-gamma responses [2].

Analytical, diagnostic and therapeutic context of Ncr3

Sequence analysis demonstrates that this putative activation receptor contains 71% identity to human NKp30 at the DNA level, suggesting that it is the rat homologue (rNKp30) [3].

References

Molecular characterization of the novel rat NK receptor 1C7. Bäckman-Petersson, E., Miller, J.R., Hollyoake, M., Aguado, B., Butcher, G.W. Eur. J. Immunol. (2003) [Pubmed]
NKp30 is a functional activation receptor on a subset of rat natural killer cells. Hsieh, C.L., Nagasaki, K., Martinez, O.M., Krams, S.M. Eur. J. Immunol. (2006) [Pubmed]
NK cells and transplantation. Hsieh, C.L., Obara, H., Ogura, Y., Martinez, O.M., Krams, S.M. Transpl. Immunol. (2002) [Pubmed]

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