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Gene Review

Trpv2  -  transient receptor potential cation...

Rattus norvegicus

Synonyms: OTRPC2, Osm-9-like TRP channel 2, Sac2b, Stretch-activated channel 2B, Transient receptor potential cation channel subfamily V member 2, ...
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Disease relevance of Trpv2


High impact information on Trpv2

  • These findings, together with our previous identification of the heat-sensitive channels VR1 and VRL-1, demonstrate that TRP channels detect temperatures over a wide range and are the principal sensors of thermal stimuli in the mammalian peripheral nervous system [2].
  • All SNS expressing A-fiber cells are Trk-A positive and many express the vanilloid-like receptor VRL1 [3].
  • Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat [1].
  • Although VRL-1 does not bind capsaicin, like VR1 it is activated by noxious heat (>52 degrees C) [1].
  • To provide information on the diverse spinal circuits that are engaged by these VRL-1-expressing primary afferents, we completed a detailed immunocytochemical map of VRL-1 in rat spinal cord, including light and electron microscopic analysis, and generated a more comprehensive neurochemical characterization of VRL-1-expressing primary afferents [1].

Anatomical context of Trpv2

  • VR1 and VRL1 immunoreactivity were observed in the intraepithelial free nerve endings, subepithelial nerve plexus and laryngeal epithelial cells [4].
  • The densest VRL-1 immunoreactivity in the spinal cord was found in lamina I, inner lamina II, and laminae III/IV [1].
  • Although we never observed VRL-1 immunostaining in cell bodies in the superficial dorsal horn, there was extensive labeling of motoneurons and ventral root efferents-in particular, in an extremely densely labeled population at the lumbosacral junction [1].
  • This is consistent with the expression of VRL-1 by myelinated nociceptors that target laminae I and IIi and in nonnociceptive Abeta fibers that target laminae III/IV [1].
  • The present study suggests that co-expression of VR1 and VRL-1 may be more common in visceral sensory neurons than in somatic sensory neurons [5].

Regulatory relationships of Trpv2


Other interactions of Trpv2


Analytical, diagnostic and therapeutic context of Trpv2


  1. Immunoreactive TRPV-2 (VRL-1), a capsaicin receptor homolog, in the spinal cord of the rat. Lewinter, R.D., Skinner, K., Julius, D., Basbaum, A.I. J. Comp. Neurol. (2004) [Pubmed]
  2. Identification of a cold receptor reveals a general role for TRP channels in thermosensation. McKemy, D.D., Neuhausser, W.M., Julius, D. Nature (2002) [Pubmed]
  3. Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2. Amaya, F., Decosterd, I., Samad, T.A., Plumpton, C., Tate, S., Mannion, R.J., Costigan, M., Woolf, C.J. Mol. Cell. Neurosci. (2000) [Pubmed]
  4. Immunolocalization of VR1 and VRL1 in rat larynx. Yamamoto, Y., Taniguchi, K. Autonomic neuroscience : basic & clinical. (2005) [Pubmed]
  5. The co-expression of VR1 and VRL-1 in the rat vagal sensory ganglia. Ichikawa, H., Sugimoto, T. Brain Res. (2003) [Pubmed]
  6. The putative role of vanilloid receptor-like protein-1 in mediating high threshold noxious heat-sensitivity in rat cultured primary sensory neurons. Ahluwalia, J., Rang, H., Nagy, I. Eur. J. Neurosci. (2002) [Pubmed]
  7. Noxious heat-induced CGRP release from rat sciatic nerve axons in vitro. Sauer, S.K., Reeh, P.W., Bove, G.M. Eur. J. Neurosci. (2001) [Pubmed]
  8. Co-expression of VRL-1 and calbindin D-28k in the rat sensory ganglia. Ichikawa, H., Sugimoto, T. Brain Res. (2002) [Pubmed]
  9. Vanilloid receptor homologue, VRL1, is expressed by both A- and C-fiber sensory neurons. Ma, Q.P. Neuroreport (2001) [Pubmed]
  10. VRL-1 immunoreactivity in the rat cranial autonomic ganglia. Ichikawa, H., Sugimoto, T. Neuroreport (2001) [Pubmed]
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