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Rgs9  -  regulator of G-protein signaling 9

Rattus norvegicus

Synonyms: RGS9, Regulator of G-protein signaling 9
 
 
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Disease relevance of Rgs9

 

High impact information on Rgs9

  • Dialysis of cholinergic neurons with RGS9 constructs enhanced basal Ca(2+) channel currents and reduced D(2) dopamine receptor modulation of Cav2.2 channels [2].
  • The pattern of RGS 9 mRNA splicing was tissue specific, with striatum, hypothalamus- and nucleus accumbens expressing RGS 9L, whereas retina and pineal expressed RGS 9S almost exclusively [1].
  • The human RGS 9 gene was localized to chromosome 17 q23-24 by radiation hybrid and fluorescent in situ hybridization analyses [1].
  • The level of RGS 9 mRNA, which shows strong striatal-specific expression, steadily decreased over a 4-h interval, whereas RGS 4 and 16 and the 3.9-kb transcript of RGS 8 were not significantly affected at any point examined [3].
  • Its selective expression suggests that RGS9 may play an important role in modulation of the complex signalling pathways of the basal ganglia [4].
 

Biological context of Rgs9

  • RGS9 has two alternative splicing variants [5].
  • Furthermore, RGS9-2 transfection increased the transcriptional activity of a neuronal gene construct normally expressed in RGS9-positive neurons, suggesting that nuclear RGS9 directly or indirectly regulates transcription in vivo [6].
 

Anatomical context of Rgs9

 

Associations of Rgs9 with chemical compounds

 

Other interactions of Rgs9

 

Analytical, diagnostic and therapeutic context of Rgs9

References

  1. Molecular characterization of human and rat RGS 9L, a novel splice variant enriched in dopamine target regions, and chromosomal localization of the RGS 9 gene. Granneman, J.G., Zhai, Y., Zhu, Z., Bannon, M.J., Burchett, S.A., Schmidt, C.J., Andrade, R., Cooper, J. Mol. Pharmacol. (1998) [Pubmed]
  2. RGS9-2 modulates D2 dopamine receptor-mediated Ca2+ channel inhibition in rat striatal cholinergic interneurons. Cabrera-Vera, T.M., Hernandez, S., Earls, L.R., Medkova, M., Sundgren-Andersson, A.K., Surmeier, D.J., Hamm, H.E. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  3. Regulators of G protein signaling: rapid changes in mRNA abundance in response to amphetamine. Burchett, S.A., Volk, M.L., Bannon, M.J., Granneman, J.G. J. Neurochem. (1998) [Pubmed]
  4. RGS9: a regulator of G-protein signalling with specific expression in rat and mouse striatum. Thomas, E.A., Danielson, P.E., Sutcliffe, J.G. J. Neurosci. Res. (1998) [Pubmed]
  5. Differential expression of the regulator of G protein signaling RGS9 protein in nociceptive pathways of different age rats. Kim, K.J., Moriyama, K., Han, K.R., Sharma, M., Han, X., Xie, G.X., Palmer, P.P. Brain Res. Dev. Brain Res. (2005) [Pubmed]
  6. Brain-specific RGS9-2 is localized to the nucleus via its unique proline-rich domain. Bouhamdan, M., Michelhaugh, S.K., Calin-Jageman, I., Ahern-Djamali, S., Bannon, M.J. Biochim. Biophys. Acta (2004) [Pubmed]
  7. Estrogen modulates RGS9 expression in the nucleus accumbens. Sharifi, J.L., Brady, D.L., Koenig, J.I. Neuroreport (2004) [Pubmed]
  8. Complexes of the G protein subunit gbeta 5 with the regulators of G protein signaling RGS7 and RGS9. Characterization in native tissues and in transfected cells. Witherow, D.S., Wang, Q., Levay, K., Cabrera, J.L., Chen, J., Willars, G.B., Slepak, V.Z. J. Biol. Chem. (2000) [Pubmed]
 
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