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Ptbp1  -  polypyrimidine tract binding protein 1

Rattus norvegicus

Synonyms: Heterogeneous nuclear ribonucleoprotein I, PTB, PYBP, Polypyrimidine tract-binding protein 1, Ptb, ...
 
 
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Disease relevance of Ptbp1

  • Our data show that hypoxia may increase insulin mRNA levels by promoting the binding of PTB to the insulin mRNA 3'-UTR [1].
 

High impact information on Ptbp1

 

Chemical compound and disease context of Ptbp1

 

Biological context of Ptbp1

 

Anatomical context of Ptbp1

  • We report the identification and characterization of a fourth rodent PTB paralog (smPTB) that is expressed at high levels in a number of smooth muscle tissues [4].
  • A novel structure-specific endonuclease activity associated with polypyrimidine-tract binding (PTB) related protein from rat testis [6].
  • In cell-free translation analysis, immunodepletion of PTB from rabbit reticulocyte lysate caused an increase in albumin translation [10].
 

Associations of Ptbp1 with chemical compounds

  • Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein [5].
  • The glucose-induced PTB-binding was only inhibited by the mTOR inhibitor rapamycin [9].
 

Analytical, diagnostic and therapeutic context of Ptbp1

References

  1. Hypoxia may increase rat insulin mRNA levels by promoting binding of the polypyrimidine tract-binding protein (PTB) to the pyrimidine-rich insulin mRNA 3'-untranslated region. Tillmar, L., Welsh, N. Mol. Med. (2002) [Pubmed]
  2. A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing. Polydorides, A.D., Okano, H.J., Yang, Y.Y., Stefani, G., Darnell, R.B. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. An intronic splicing silencer causes skipping of the IIIb exon of fibroblast growth factor receptor 2 through involvement of polypyrimidine tract binding protein. Carstens, R.P., Wagner, E.J., Garcia-Blanco, M.A. Mol. Cell. Biol. (2000) [Pubmed]
  4. A novel polypyrimidine tract-binding protein paralog expressed in smooth muscle cells. Gooding, C., Kemp, P., Smith, C.W. J. Biol. Chem. (2003) [Pubmed]
  5. Cloning and sequencing of PYBP, a pyrimidine-rich specific single strand DNA-binding protein. Brunel, F., Alzari, P.M., Ferrara, P., Zakin, M.M. Nucleic Acids Res. (1991) [Pubmed]
  6. A novel structure-specific endonuclease activity associated with polypyrimidine-tract binding (PTB) related protein from rat testis. Haldar, D., Acharya, S., Rao, M.R. Biochemistry (2002) [Pubmed]
  7. Splicing of a myosin phosphatase targeting subunit 1 alternative exon is regulated by intronic cis-elements and a novel bipartite exonic enhancer/silencer element. Dirksen, W.P., Mohamed, S.A., Fisher, S.A. J. Biol. Chem. (2003) [Pubmed]
  8. A high affinity binding site for the polypyrimidine tract binding protein (PTB) is located in the 5'-untranslated region of the rat proteinase alpha1-inhibitor 3 variant I gene. Sickinger, S., Schweizer, M. Biol. Chem. (1999) [Pubmed]
  9. Glucose-induced binding of the polypyrimidine tract-binding protein (PTB) to the 3'-untranslated region of the insulin mRNA (ins-PRS) is inhibited by rapamycin. Tillmar, L., Welsh, N. Mol. Cell. Biochem. (2004) [Pubmed]
  10. Posttranscriptional regulation of albumin gene expression by branched-chain amino acids in rats with acute liver injury. Kuwahata, M., Kuramoto, Y., Tomoe, Y., Sugata, E., Segawa, H., Ito, M., Oka, T., Miyamoto, K. Biochim. Biophys. Acta (2004) [Pubmed]
 
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