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Kcnk3  -  potassium channel, two pore domain...

Rattus norvegicus

Synonyms: Acid-sensitive potassium channel protein TASK-1, Potassium channel subfamily K member 3, TWIK-related acid-sensitive K(+) channel 1, Task, Task-1, ...
 
 
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High impact information on Kcnk3

  • When exogenously expressed in Xenopus oocytes, rTASK currents activate instantaneously, are noninactivating, and are not gated by voltage [1].
  • The World Health Organisation (WHO) Task Force on Birth Control Vaccines has selected the pregnancy hormone human chorionic gonadotropin (hCG) as a target molecule for a contraceptive vaccine [2].
  • METHODS: The Visual Water Task was used to quantify the grating acuity of pigmented dystrophic RCS rats as they aged and to compare both grating acuity and contrast sensitivity in nondystrophic RCS rats with those parameters in normal pigmented laboratory rats (Long-Evans) [3].
  • Male rats were trained in the Morris Water Task after microinjection with different doses of dynorphin B (1, 3.3 or 10 nmol/rat) or artificial cerebrospinal fluid (as control) into the CA3 region of the dorsal hippocampus [4].
  • CONCLUSIONS: Task performance was disrupted to a much greater extent by co-administration of alcohol and nicotine than by alcohol alone; therefore, it seems unlikely that an ability of nicotine to reverse the effects of alcohol can account for associations between the use of the two substances [5].
 

Associations of Kcnk3 with chemical compounds

  • Likewise, evoked D-ASP release from hippocampal slices and performance on a standard version of the Morris Water Task were not affected by prenatal ethanol exposure [6].
  • The Corridor Task: a simple test of lateralised response selection sensitive to unilateral dopamine deafferentation and graft-derived dopamine replacement in the striatum [7].
  • The purpose of this study was to determine the effects of the benzodiazepines, midazolam and chlordiazepoxide, and the barbiturate, pentobarbital, on spatial learning, in a within-subject, repeated-acquisition and performance procedure adapted to the Morris Swim Task [8].
  • Effects of morphine and 2 N-methyl-D-aspartate (NMDA) receptor antagonists, phencyclidine and LY235959, were studied using a within-subject, repeated-acquisition/performance procedure adapted to the Morris Swim Task [9].

References

  1. An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum. Leonoudakis, D., Gray, A.T., Winegar, B.D., Kindler, C.H., Harada, M., Taylor, D.M., Chavez, R.A., Forsayeth, J.R., Yost, C.S. J. Neurosci. (1998) [Pubmed]
  2. Functional and immunological relevance of the COOH-terminal extension of human chorionic gonadotropin beta: implications for the WHO birth control vaccine. Dirnhofer, S., Klieber, R., De Leeuw, R., Bidart, J.M., Merz, W.E., Wick, G., Berger, P. FASEB J. (1993) [Pubmed]
  3. Quantification of spatial vision in the Royal College of Surgeons rat. McGill, T.J., Douglas, R.M., Lund, R.D., Prusky, G.T. Invest. Ophthalmol. Vis. Sci. (2004) [Pubmed]
  4. Hippocampal dynorphin B injections impair spatial learning in rats: a kappa-opioid receptor-mediated effect. Sandin, J., Nylander, I., Georgieva, J., Schött, P.A., Ogren, S.O., Terenius, L. Neuroscience (1998) [Pubmed]
  5. Comprehensive deficits in performance of an attentional task produced by co-administering alcohol and nicotine to rats. Bizarro, L., Patel, S., Stolerman, I.P. Drug and alcohol dependence. (2003) [Pubmed]
  6. Dose-dependent effects of prenatal ethanol exposure on synaptic plasticity and learning in mature offspring. Savage, D.D., Becher, M., de la Torre, A.J., Sutherland, R.J. Alcohol. Clin. Exp. Res. (2002) [Pubmed]
  7. The Corridor Task: a simple test of lateralised response selection sensitive to unilateral dopamine deafferentation and graft-derived dopamine replacement in the striatum. Dowd, E., Monville, C., Torres, E.M., Dunnett, S.B. Brain Res. Bull. (2005) [Pubmed]
  8. Effects of positive GABA(A) modulators on a multiple-component, repeated-acquisition test of spatial learning. Keith, J.R., Pitts, R.C., Pezzuti, T., Galizio, M. Behavioural pharmacology. (2003) [Pubmed]
  9. Repeated spatial acquisition: effects of NMDA antagonists and morphine. Galizio, M., Keith, J.R., Mansfield, W.J., Pitts, R.C. Experimental and clinical psychopharmacology. (2003) [Pubmed]
 
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