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Psme2  -  proteasome (prosome, macropain) activator...

Rattus norvegicus

Synonyms: 11S regulator complex subunit beta, Activator of multicatalytic protease subunit 2, PA28b, PA28beta, Proteasome activator 28 subunit beta, ...
 
 
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High impact information on Psme2

  • Here we show that, in addition to the decreased levels of expression of the MHC class I heavy chain and the peptide transporter Tap-2, the expression levels of the chaperone Tapasin and the immunoproteasome components MECL-1, PA28-alpha, and PA28-beta also are much lower in Ad12- than in Ad5-transformed BRK cells [1].
  • PA28 alpha and PA28 beta were coordinately regulated by gamma-interferon, which greatly induced mRNA levels of both proteins in cultured cells [2].

References

  1. Differential expression of tapasin and immunoproteasome subunits in adenovirus type 5- versus type 12-transformed cells. Vertegaal, A.C., Kuiperij, H.B., Houweling, A., Verlaan, M., van der Eb, A.J., Zantema, A. J. Biol. Chem. (2003) [Pubmed]
  2. Primary structures of two homologous subunits of PA28, a gamma-interferon-inducible protein activator of the 20S proteasome. Ahn, J.Y., Tanahashi, N., Akiyama, K., Hisamatsu, H., Noda, C., Tanaka, K., Chung, C.H., Shibmara, N., Willy, P.J., Mott, J.D. FEBS Lett. (1995) [Pubmed]
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