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Gene Review:

Pacsin1 - protein kinase C and casein kinase...

Rattus norvegicus

Synonyms: Dynamin PRD-interacting protein, Dynamin proline-rich domain-interacting protein, Protein kinase C and casein kinase substrate in neurons protein 1, SdpI, Synaptic, dynamin-associated protein I, ...

Qualmann, B. et al., Anggono, V. et al., Kessels, M.M. et al., Braun, A. et al., Wasiak, S. et al., et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Pacsin1

Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis [1].
Instead, we found it recruits syndapin I for SVE and does not control amphiphysin or endophilin binding in rat synaptosomes [1].
An in vivo reconstitution of the syndapin-N-WASP interaction at cellular membranes triggered local actin polymerization [2].
We here report the identification and characterization of SdpII, a ubiquitously expressed isoform of the brain-specific SdpI [3].
The src homology 3 (SH3) domain of SdpI and -II inhibited receptor-mediated internalization of transferrin, demonstrating syndapin involvement in endocytosis in vivo [3].

Biological context of Pacsin1

Syndapin isoforms participate in receptor-mediated endocytosis and actin organization [3].
Thus syndapin I is a central component of the endocytic protein complex for SVE via stimulus-dependent recruitment to dynamin I and has a key role in synaptic transmission [1].

Anatomical context of Pacsin1

Syndapin I (SdpI) interacts with proteins involved in endocytosis and actin dynamics and was therefore proposed to be a molecular link between the machineries for synaptic vesicle recycling and cytoskeletal organization [3].
Heterologous and endogenous coimmunoprecipitations as well as reconstitutions of syndapin/EHD protein complexes at intracellular membranes of living cells demonstrate the in vivo relevance of the interaction [4].
The syndapin protein family: linking membrane trafficking with the cytoskeleton [5].
Syndapin-dynamin complexes appear to play an important role in vesicle fission at different donor membranes, including the plasma membrane (endocytosis) and Golgi membranes [5].
The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors [6].

Other interactions of Pacsin1

Mass spectrometry analysis and immunodepletion studies reveal p50 as PACSIN 1/syndapin I, a Src homology 3 domain-containing protein functioning in endocytosis and regulation of actin dynamics [7].

References

Syndapin I is the phosphorylation-regulated dynamin I partner in synaptic vesicle endocytosis. Anggono, V., Smillie, K.J., Graham, M.E., Valova, V.A., Cousin, M.A., Robinson, P.J. Nat. Neurosci. (2006) [Pubmed]
Syndapins integrate N-WASP in receptor-mediated endocytosis. Kessels, M.M., Qualmann, B. EMBO J. (2002) [Pubmed]
Syndapin isoforms participate in receptor-mediated endocytosis and actin organization. Qualmann, B., Kelly, R.B. J. Cell Biol. (2000) [Pubmed]
EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling. Braun, A., Pinyol, R., Dahlhaus, R., Koch, D., Fonarev, P., Grant, B.D., Kessels, M.M., Qualmann, B. Mol. Biol. Cell (2005) [Pubmed]
The syndapin protein family: linking membrane trafficking with the cytoskeleton. Kessels, M.M., Qualmann, B. J. Cell. Sci. (2004) [Pubmed]
The regulatory subunit of PDE6 interacts with PACSIN in photoreceptors. Houdart, F., Girard-Nau, N., Morin, F., Voisin, P., Vannier, B. Mol. Vis. (2005) [Pubmed]
The Ras/Rac guanine nucleotide exchange factor mammalian Son-of-sevenless interacts with PACSIN 1/syndapin I, a regulator of endocytosis and the actin cytoskeleton. Wasiak, S., Quinn, C.C., Ritter, B., de Heuvel, E., Baranes, D., Plomann, M., McPherson, P.S. J. Biol. Chem. (2001) [Pubmed]

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PACSIN1	Bos taurus
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pacsin1b	Danio rerio
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