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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Cacna1d  -  calcium channel, voltage-dependent, L type...

Rattus norvegicus

Synonyms: Cach3, Cacn4, Cacnl1a2, Cchl1a2, RBD, ...
 
 
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High impact information on Cacna1d

  • Stau-RBD expression was restricted to the cell bodies and proximal dendrites [1].
  • Transient expression of RalGDS-RBD or Rap1GAP to block the Rap1 pathway reduces the NGF-dependent neurite outgrowth in PC12-Shb cells [2].
  • The wet weight of the soleus muscle (SOL) only in the RB and RBD was significantly greater than in the CON [3].
  • Rats were divided into three groups; the sham-operated group (CON), Stroke (RB) and Stroke plus severed right sciatic nerve (RBD) [3].
  • The present study investigated the effects of RBD-induced malnutrition on resting blood pressure and baroreflex sensitivity in conscious rats [4].
 

Biological context of Cacna1d

  • The deduced protein contained one consensus sequence of RNA-binding domain (CS-RBD) and a glycine rich domain (GRD) [5].
  • The effects of 1-week restrictions on SD were less evident in the pups malnourished during the second week of lactation and were more evident in pups receiving the RBD during the third week [6].

References

  1. A role for a rat homolog of staufen in the transport of RNA to neuronal dendrites. Tang, S.J., Meulemans, D., Vazquez, L., Colaco, N., Schuman, E. Neuron (2001) [Pubmed]
  2. NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway. Lu, L., Annerén, C., Reedquist, K.A., Bos, J.L., Welsh, M. Exp. Cell Res. (2000) [Pubmed]
  3. Histochemical characterization of skeletal muscles in rats with photochemically-induced stroke. Abo, M., Miyano, S., Eun, S.S., Yamauchi, H. Brain injury : [BI]. (2004) [Pubmed]
  4. Influence of a multideficient diet from northeastern Brazil on resting blood pressure and baroreflex sensitivity in conscious, freely moving rats. Monteiro, F.M., Lahlou, S., Albuquerque, J.A., Cabral, A.M. Braz. J. Med. Biol. Res. (2001) [Pubmed]
  5. Cloning and characterization of amphibian cold inducible RNA-binding protein. Saito, T., Sugimoto, K., Adachi, Y., Wu, Q., Mori, K.J. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2000) [Pubmed]
  6. Spreading depression is facilitated in adult rats previously submitted to short episodes of malnutrition during the lactation period. Rocha-de-Melo, A.P., Guedes, R.C. Braz. J. Med. Biol. Res. (1997) [Pubmed]
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